Reactome | Calmodulin dissociates KRAS4B from the plasma membrane

Calmodulin dissociates KRAS4B from the plasma membrane

Stable Identifier

R-HSA-9654521

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Calmodulin dissociates KRAS4B from the plasma membrane

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Ca2+/calmodulin-binding to KRAS4B dissociates it from the plasma membrane independent of nucleotide state (Firaz et al, 2005; Sidhu et al, 2003; Sperlich et al, 2016; reviewed in Shimashu et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
16043511	Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin Meyer, T, Fivaz, M	J. Cell Biol.	2005
27410739	Regulation of K-Ras4B Membrane Binding by Calmodulin Weise, K, Waldmann, H, Winter, R, Sperlich, B, Kapoor, S	Biophys. J.	2016
28666118	RAS Proteins and Their Regulators in Human Disease McCormick, F, Nissley, DV, Simanshu, DK	Cell	2017
12727204	Ca2+/calmodulin binds and dissociates K-RasB from membrane Bhullar, RP, Clough, RR, Sidhu, RS	Biochem. Biophys. Res. Commun.	2003