Calmodulin dissociates KRAS4B from the plasma membrane

Stable Identifier
R-HSA-9654521
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Calmodulin dissociates KRAS4B from the plasma membrane
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Ca2+/calmodulin-binding to KRAS4B dissociates it from the plasma membrane independent of nucleotide state (Firaz et al, 2005; Sidhu et al, 2003; Sperlich et al, 2016; reviewed in Shimashu et al, 2017).
Literature References
PubMed ID Title Journal Year
16043511 Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin

Fivaz, M, Meyer, T

J. Cell Biol. 2005
27410739 Regulation of K-Ras4B Membrane Binding by Calmodulin

Sperlich, B, Kapoor, S, Waldmann, H, Winter, R, Weise, K

Biophys. J. 2016
28666118 RAS Proteins and Their Regulators in Human Disease

Simanshu, DK, Nissley, DV, McCormick, F

Cell 2017
12727204 Ca2+/calmodulin binds and dissociates K-RasB from membrane

Sidhu, RS, Clough, RR, Bhullar, RP

Biochem. Biophys. Res. Commun. 2003
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Orthologous Events
Calmodulin dissociates KRAS4B from the plasma membrane (Bos taurus)
Calmodulin dissociates KRAS4B from the plasma membrane (Caenorhabditis elegans)
Calmodulin dissociates KRAS4B from the plasma membrane (Canis familiaris)
Calmodulin dissociates KRAS4B from the plasma membrane (Drosophila melanogaster)
Calmodulin dissociates KRAS4B from the plasma membrane (Mus musculus)
Calmodulin dissociates KRAS4B from the plasma membrane (Rattus norvegicus)
Authored
Rothfels, K  (2019-10-25)
Reviewed
Gavathiotis, E  (2020-05-04)
Created
Rothfels, K  (2019-07-18)
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