pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PKC- or -PRKG2-dependent phosphorylation of KRAS4B at serine 181 promotes its trafficking to intracellular membranes, including the mitochondrial outer membrane where it interacts with BCL2L1 (also known as BCL-XL) to promote apoptosis (Bivona et al, 2006; Barcelo et al, 2013; Jang et al, 2015; reviewed in Ahearn et al, 2018).
Literature References
PubMed ID Title Journal Year
23943869 Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status

Tebar, F, Beckett, AJ, Agell, N, Barceló, C, Prior, I, Paco, N, Jaumot, M, Alvarez-Moya, B, Garrido, E, Gelabert, M

J. Cell. Sci. 2013
29311131 Posttranslational Modifications of RAS Proteins

Philips, MR, Zhou, M, Ahearn, I

Cold Spring Harb Perspect Med 2018
16483930 PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis

Philips, MR, Bivona, TG, Thompson, CB, Ahearn, IM, Mor, A, Pérez De Castro, I, Saba, SG, Yim, D, Cox, AD, Bodemann, BO, Wiener, HH, Soskis, MJ, Fein, A, Miura, J, Quatela, SE, Li, C, Wright, L

Mol. Cell 2006
25713064 Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region

Nussinov, R, Tarasova, NI, Khavrutskii, L, Jang, H, Abraham, SJ, Gaponenko, V, Hitchinson, B, Chavan, TS

J. Biol. Chem. 2015
Orthologous Events
Cite Us!