USP17L2, also known as USP17, deubiquitinates RCE1 (RAS-converting enzyme 1), inactivating it. Loss of RCE1 activity after USP17L2-mediated deubiquitination interferes with RAS localization and function and prevents downstream signaling through the RAF MAP kinase cascade (Burrows et al, 2009).
Burrows, JF, Kelvin, AA, McFarlane, C, Burden, RE, McGrattan, MJ, De la Vega, M, Govender, U, Quinn, DJ, Dib, K, Gadina, M, Scott, CJ, Johnston, JA
thiol-dependent ubiquitin-specific protease activity of USP17L2 [cytosol]
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