USP17L2 deubiquitinates RCE1

Stable Identifier
R-HSA-9653514
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP17L2, also known as USP17, deubiquitinates RCE1 (RAS-converting enzyme 1), inactivating it. Loss of RCE1 activity after USP17L2-mediated deubiquitination interferes with RAS localization and function and prevents downstream signaling through the RAF MAP kinase cascade (Burrows et al, 2009).

Literature References
PubMed ID Title Journal Year
19188362 USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity

Burrows, JF, Kelvin, AA, McFarlane, C, Burden, RE, McGrattan, MJ, De la Vega, M, Govender, U, Quinn, DJ, Dib, K, Gadina, M, Scott, CJ, Johnston, JA

J. Biol. Chem. 2009
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP17L2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
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