USP17L2 deubiquitinates RCE1

Stable Identifier
R-HSA-9653514
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP17L2, also known as USP17, deubiquitinates RCE1 (RAS-converting enzyme 1), inactivating it. Loss of RCE1 activity after USP17L2-mediated deubiquitination interferes with RAS localization and function and prevents downstream signaling through the RAF MAP kinase cascade (Burrows et al, 2009).

Literature References
PubMed ID Title Journal Year
19188362 USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity

Burrows, JF, Kelvin, AA, McFarlane, C, Burden, RE, McGrattan, MJ, De la Vega, M, Govender, U, Quinn, DJ, Dib, K, Gadina, M, Scott, CJ, Johnston, JA

J. Biol. Chem. 2009
Participants
Participates
Catalyst Activity

thiol-dependent ubiquitin-specific protease activity of USP17L2 [cytosol]

Orthologous Events
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