Signaling by MAPK mutants

Stable Identifier
Homo sapiens
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Mutations in ERK proteins (MAPK1 and MAPK2) are rare, with mutations reported in ~8% of cervical cancers and 1.5% of head and neck squamous cell carcinomas (Ojesina et al, 2014; Cancer Genome Atlas, 2015; reviewed in Najafi et al, 2019). MAPK proteins with activating mutations are often still dependent on upstream phosphorylation by MAP2K proteins, but support sustained downstream signaling by virtue of being resistant to inactivating dephosphorylations (reviewed in Samatar and Poulikakos, 2014; Liu et al, 2018).
Literature References
PubMed ID Title Journal Year
25631445 Comprehensive genomic characterization of head and neck squamous cell carcinomas

The Cancer Genome Atlas Network, -

Nature 2015
24390348 Landscape of genomic alterations in cervical carcinomas

Carey, TE, Cherniack, AD, Getz, G, Lawrence, MS, Cibulskis, K, Akslen, LA, Pedamallu, CS, Nickerson, E, Rodea, C, Bjorge, L, Treviño, V, Greulich, H, Hidalgo-Miranda, A, Freeman, SS, Bertelsen, B, Pugh, TJ, Rodriguez-Sanchez, IP, Wang, R, Melendez-Zajgla, J, Neuberg, DS, Lichtenstein, L, Escareno, CR, Wright, AA, Barrera-Saldaña, HA, Vazquez, J, Gabiño, NB, Krakstad, C, Salvesen, HB, Meyerson, M, Halle, MK, Carter, SL, Cravioto, A, Garza-Rodríguez, ML, Ambrogio, L, Vazquez-Santillan, K, Kaplan, B, Hoivik, EA, Ojesina, AI, Vintermyr, OK, Gabriel, SB, McKenna, A, Guadarrama, AS, Cortes, ML, Espinosa-Castilla, M, Walline, HM, Rosenberg, MW, Stewart, C, Maytorena, G, Gómez-Macías, GS, Imaz-Rosshandler, I, Crum, CP, Valdez-Chapa, LD, Romero-Cordoba, S, Duke, F, Wik, E, Woie, K

Nature 2014
25435214 Targeting RAS-ERK signalling in cancer: promises and challenges

Poulikakos, PI, Samatar, AA

Nat Rev Drug Discov 2014
31136035 Extracellular-signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling as a target for cancer therapy: An updated review

Ahmadi, A, Mortezaee, K, Najafi, M

Cell Biol. Int. 2019
30109180 Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

Liu, F, Geng, M, Huang, M, Yang, X

Acta Pharm Sin B 2018
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
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