Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs

Stable Identifier
Reaction [transition]
Homo sapiens
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Constitutively active forms of MAPK1 have been identified at low frequency in a number of cancers (Ojesina et al, 2014; TCGA, 2015). These mutants are not susceptible to DUSP-mediated dephosphorylation and so promote sustained signaling (Brenan et al, 2016).

Literature References
PubMed ID Title Journal Year
27760319 Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

Brenan, L, Andreev, A, Cohen, O, Pantel, S, Kamburov, A, Cacchiarelli, D, Persky, NS, Zhu, C, Bagul, M, Goetz, EM, Burgin, AB, Garraway, LA, Getz, G, Mikkelsen, TS, Piccioni, F, Root, DE, Johannessen, CM

Cell Rep 2016
25631445 Comprehensive genomic characterization of head and neck squamous cell carcinomas

The Cancer Genome Atlas Network, -

Nature 2015
24390348 Landscape of genomic alterations in cervical carcinomas

Ojesina, AI, Lichtenstein, L, Freeman, SS, Pedamallu, CS, Imaz-Rosshandler, I, Pugh, TJ, Cherniack, AD, Ambrogio, L, Cibulskis, K, Bertelsen, B, Romero-Cordoba, S, Treviño, V, Vazquez-Santillan, K, Guadarrama, AS, Wright, AA, Rosenberg, MW, Duke, F, Kaplan, B, Wang, R, Nickerson, E, Walline, HM, Lawrence, MS, Stewart, C, Carter, SL, McKenna, A, Rodriguez-Sanchez, IP, Espinosa-Castilla, M, Woie, K, Bjorge, L, Wik, E, Halle, MK, Hoivik, EA, Krakstad, C, Gabiño, NB, Gómez-Macías, GS, Valdez-Chapa, LD, Garza-Rodríguez, ML, Maytorena, G, Vazquez, J, Rodea, C, Cravioto, A, Cortes, ML, Greulich, H, Crum, CP, Neuberg, DS, Hidalgo-Miranda, A, Escareno, CR, Akslen, LA, Carey, TE, Vintermyr, OK, Gabriel, SB, Barrera-Saldaña, HA, Melendez-Zajgla, J, Getz, G, Salvesen, HB, Meyerson, M

Nature 2014
Participant Of
Catalyst Activity
Catalyst Activity
protein tyrosine/serine/threonine phosphatase activity of cytosolic MAPK DUSPs [cytosol]
Physical Entity
Normal reaction
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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