Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs

Stable Identifier
Reaction [transition]
Homo sapiens
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Constitutively active forms of MAPK1 have been identified at low frequency in a number of cancers (Ojesina et al, 2014; TCGA, 2015). These mutants are not susceptible to DUSP-mediated dephosphorylation and so promote sustained signaling (Brenan et al, 2016).
Literature References
PubMed ID Title Journal Year
25631445 Comprehensive genomic characterization of head and neck squamous cell carcinomas

The Cancer Genome Atlas Network, -

Nature 2015
27760319 Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

Pantel, S, Garraway, LA, Johannessen, CM, Cacchiarelli, D, Getz, G, Persky, NS, Brenan, L, Piccioni, F, Cohen, O, Root, DE, Goetz, EM, Zhu, C, Andreev, A, Burgin, AB, Mikkelsen, TS, Bagul, M, Kamburov, A

Cell Rep 2016
24390348 Landscape of genomic alterations in cervical carcinomas

Carey, TE, Cherniack, AD, Getz, G, Lawrence, MS, Cibulskis, K, Akslen, LA, Pedamallu, CS, Nickerson, E, Rodea, C, Bjorge, L, Treviño, V, Greulich, H, Hidalgo-Miranda, A, Freeman, SS, Bertelsen, B, Pugh, TJ, Rodriguez-Sanchez, IP, Wang, R, Melendez-Zajgla, J, Neuberg, DS, Lichtenstein, L, Escareno, CR, Wright, AA, Barrera-Saldaña, HA, Vazquez, J, Gabiño, NB, Krakstad, C, Salvesen, HB, Meyerson, M, Halle, MK, Carter, SL, Cravioto, A, Garza-Rodríguez, ML, Ambrogio, L, Vazquez-Santillan, K, Kaplan, B, Hoivik, EA, Ojesina, AI, Vintermyr, OK, Gabriel, SB, McKenna, A, Guadarrama, AS, Cortes, ML, Espinosa-Castilla, M, Walline, HM, Rosenberg, MW, Stewart, C, Maytorena, G, Gómez-Macías, GS, Imaz-Rosshandler, I, Crum, CP, Valdez-Chapa, LD, Romero-Cordoba, S, Duke, F, Wik, E, Woie, K

Nature 2014
Catalyst Activity

protein tyrosine/serine/threonine phosphatase activity of cytosolic MAPK DUSPs [cytosol]

Normal reaction
Functional status

Loss of function of constitutively active MAPK1 mutants [cytosol]

Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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