PtpA binds ATP6V1H

Stable Identifier
R-HSA-9636397
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PtpA binds ATP6V1H
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The H subunit of human cytosolic ATPase (ATP6V1H) binds to the Mtb probable low molecular weight protein-tyrosine phosphatase (ptpA), directly impairing ATPase trafficking to the phagosome (Wong et al. 2011).

Literature References
PubMed ID Title Journal Year
22087003 Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification

Wong, D, Bach, H, Sun, J, Hmama, Z, Av-Gay, Y

Proc. Natl. Acad. Sci. U.S.A. 2011
Participants
Input
Output
Participant Of
hasEvent
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-06)
Reviewed
Deffur, A  (2019-10-23)
Wilkinson, RJ  (2019-10-23)
Created
Koile, I  (2019-02-13)