Inhibition of membrane repair

Stable Identifier
R-HSA-9635644
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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When the phagosomal membrane is injured, this is sensed and acted upon both by the host phagocyte and Mtb. While the host repair system is activated, the bacterium is secreting proteins that block host repair components, effectively inhibiting repair (Mittal et al. 2018).

Literature References
PubMed ID Title Journal Year
30482832 Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response

Mittal, E, Skowyra, ML, Uwase, G, Tinaztepe, E, Mehra, A, Köster, S, Hanson, PI, Philips, JA

MBio 2018
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
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