Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer

Stable Identifier
R-HSA-9634402
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer
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Both GRB2 and SHC1 are recruited to autophosphorylated ERBB2 homodimers (Pickl and Ries 2009). It is assumed, by analogy to the behavior of normal ERBB2 heterodimers, that GRB2 is recruited to ERBB2 homodimers through SHC1, and that GRB2 is in complex with SOS1.

Literature References
Participants
Input
Output
Participates
as an event of
Normal reaction
Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers (Homo sapiens)
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2019-07-31)
Reviewed
Kancha, RK  (2019-09-16)
Created
Orlic-Milacic, M  (2019-01-10)
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