Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer

Stable Identifier
R-HSA-9634402
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Both GRB2 and SHC1 are recruited to autophosphorylated ERBB2 homodimers (Pickl and Ries 2009). It is assumed, by analogy to the behavior of normal ERBB2 heterodimers, that GRB2 is recruited to ERBB2 homodimers through SHC1, and that GRB2 is in complex with SOS1.

Literature References
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created