Reactome | Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers

Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers

Stable Identifier

R-HSA-1250486

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

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Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers

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Phosphorylated SHC1 bound to phosphorylated ERBB2 dimers recruits GRB2:SOS1 complex (Xie et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
8530511	Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu Xie, Y, Pendergast, AM, Hung, MC	J Biol Chem	1995

Participants

Input

Output

GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

SHC1 events in ERBB2 signaling

Inferred From

Recruitment of GRB2:Sos1 to P-Shc1:P-Erbb2mut complex (Homo sapiens)

Authored

Orlic-Milacic, M (2011-11-04)

Reviewed

Neckers, LM (2011-11-11)

Xu, W (2011-11-11)

Created

Orlic-Milacic, M (2011-04-21)