Reactome | JMJD6 dimer hydroxylates lysine residues of U2AF2

JMJD6 dimer hydroxylates lysine residues of U2AF2

Stable Identifier

R-HSA-9630022

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

2-oxoglutarate + L-lysyl-(protein) + O2 => (5S)-5-hydroxy-L-lysyl-(protein) + CO2 + succinate

ReviewStatus

3/5

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JMJD6 dimer hydroxylates lysine residues of U2AF2

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Nuclear JMJD6 (JmjC domain-containing protein 6) catalyzes the hydroxylation of the 5-carbons of two lysine residues of U2AF2 (splicing factor U2AF 65 kDa subunit, also known as U2AF65) (Webby et al. 2009; Unoki et al. 2013). The active form of the protein is associated with Fe2+. The protein crystallizes as dimers (Mantri et al. 2010) and can form larger oligomers in solution (Hahn et al. 2010). For simplicity, the active form of the enzyme is annotated here as a dimer.

JMJD6 has also been reported to have histone demethylase activity (Chang et al. 2007). This activity has been annotated as part of Reactome pathway R-HSA-321842 "HDMs demethylate histones".

Literature References

PubMed ID	Title	Journal	Year
19574390	Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing Webby, CJ, Wolf, A, Gromak, N, Dreger, M, Kramer, H, Kessler, B, Nielsen, ML, Schmitz, C, Butler, DS, Yates, JR, Delahunty, CM, Hahn, P, Lengeling, A, Mann, M, Proudfoot, NJ, Schofield, CJ, Böttger, A	Science	2009
21060799	Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation Hahn, P, Wegener, I, Burrells, A, Böse, J, Wolf, A, Erck, C, Butler, DS, Schofield, CJ, Böttger, A, Lengeling, A	PLoS ONE	2010
23303181	Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6) Unoki, M, Masuda, A, Dohmae, N, Arita, K, Yoshimatsu, M, Iwai, Y, Fukui, Y, Ueda, K, Hamamoto, R, Shirakawa, M, Sasaki, H, Nakamura, Y	J. Biol. Chem.	2013
20684070	Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6 Mantri, M, Krojer, T, Bagg, EA, Webby, CJ, Butler, DS, Kochan, G, Kavanagh, KL, Oppermann, U, McDonough, MA, Schofield, CJ	J. Mol. Biol.	2010
17947579	JMJD6 is a histone arginine demethylase Chang, B, Chen, Y, Zhao, Y, Bruick, RK	Science	2007