Reactome | Protein hydroxylation

Protein hydroxylation

Stable Identifier

R-HSA-9629569

Type

Pathway

Species

Homo sapiens

ReviewStatus

3/5

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This pathway groups reactions mediated by 2-OG (2-oxoglutarate)-dependent oxygenases that target proline, lysine, asparagine, arginine, aspartate, and histidine residues of diverse proteins, with effects that potentially modulate transcription and translation (Herr & Hausinger 2018; Markolovic et al. 2015; Stoehr et al. 2016; Zurlo et al. 2016).

The roles of members of this enzyme family in collagen assembly are annotated separately in pathway R-HSA-1650814, "Collagen biosynthesis and modifying enzymes".

Literature References

PubMed ID	Title	Journal	Year
27095734	Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes Murphy, E, Kloner, PH, Evangelista, AM, Lin, Y, Wang, G, Aponte, A, Boylston, J, Stoehr, A, Zhu, J, Yang, Y, Gucek, M, Patel, S, Liu, P	Cardiovasc. Res.	2016
29709390	Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases Hausinger, RP, Herr, CQ	Trends Biochem. Sci.	2018
26152730	Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases Markolovic, S, Schofield, CJ, Wilkins, SE	J. Biol. Chem.	2015
27663420	New Insights into Protein Hydroxylation and Its Important Role in Human Diseases Zurlo, G, Takada, M, Zhang, Q, Wei, W, Guo, J	Biochim. Biophys. Acta	2016