NEIL3 cleaves 5-guanidinohydantoin

Stable Identifier
R-HSA-9629470
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NEIL3 cleaves oxidatively damaged guanin in the form of 5-guanidinohydantoin with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA), producing and abasic site (AP site) (Liu et al. 2010, Krokeide et al. 2013).

Literature References
PubMed ID Title Journal Year
23755964 Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

Krokeide, SZ, Laerdahl, JK, Salah, M, Luna, L, Cederkvist, FH, Fleming, AM, Burrows, CJ, Dalhus, B, Bjørås, M

DNA Repair (Amst.) 2013
Participants
Participates
Catalyst Activity

DNA N-glycosylase activity of NEIL3:Gh-DNA [nucleoplasm]

Orthologous Events
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