NEIL3 cleaves 5-guanidinohydantoin

Stable Identifier
R-HSA-9629470
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL3 cleaves 5-guanidinohydantoin
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NEIL3 cleaves oxidatively damaged guanin in the form of 5-guanidinohydantoin with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA), producing and abasic site (AP site) (Liu et al. 2010, Krokeide et al. 2013).
Literature References
PubMed ID Title Journal Year
23755964 Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

Krokeide, SZ, Laerdahl, JK, Salah, M, Luna, L, Cederkvist, FH, Fleming, AM, Burrows, CJ, Dalhus, B, Bjørås, M

DNA Repair (Amst.) 2013
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Input
Output
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as an event of
Catalyst Activity

DNA N-glycosylase activity of NEIL3:Gh-DNA [nucleoplasm]

Physical Entity
NEIL3:Gh-DNA [nucleoplasm] (Homo sapiens)
Activity
DNA N-glycosylase activity (GO:0019104)
Orthologous Events
NEIL3 cleaves 5-guanidinohydantoin (Bos taurus)
NEIL3 cleaves 5-guanidinohydantoin (Canis familiaris)
NEIL3 cleaves 5-guanidinohydantoin (Danio rerio)
NEIL3 cleaves 5-guanidinohydantoin (Gallus gallus)
NEIL3 cleaves 5-guanidinohydantoin (Mus musculus)
NEIL3 cleaves 5-guanidinohydantoin (Rattus norvegicus)
NEIL3 cleaves 5-guanidinohydantoin (Sus scrofa)
NEIL3 cleaves 5-guanidinohydantoin (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Zhou, J  (2019-02-11)
Created
Orlic-Milacic, M  (2018-11-21)
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