Reactome | SEPT4 binds XIAP

SEPT4 binds XIAP

Stable Identifier

R-HSA-9627369

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SEPT4 (known also as ARTS, an apoptosis-related protein in the TGF-beta signaling pathway) is a pro-apoptotic mitochondrial protein (Gottfried Y et al. 2004). SEPT4 is an unique member of the septin family which functions as a tumor suppressor. SEPT4 promotes apoptosis through binding and antagonizing inhibitor of apoptosis (IAP) proteins and specifically X linked IAP (XIAP) (Gottfried Y et al. 2004). NMR and fluorescence spectroscopy showed that the C-terminal domain (CTD) of SEPT4 directly binds BIR3 domain of XIAP. The BIR3 interacting region in SEPT4 CTD was mapped to SEPT4 residues 266 - 274, which are the nine C-terminal residues in the protein (Bornstein B et al. 2011; Reingewertz TH et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21949740	Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP Reingewertz, TH, Lebendiker, M, Shalev, DE, Rotem-Bamberger, S, Sukenik, S, Friedler, A, Larisch, S, Blatt, O	PLoS ONE	2011
21695558	ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists Bornstein, B, Gottfried, Y, Larisch, S, Lev, T, Edison, N, Glaser, F, Shekhtman, A	Apoptosis	2011