SMAC, XIAP-regulated apoptotic response

Stable Identifier
R-HSA-111469
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
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SMAC, XIAP-regulated apoptotic response
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Once released from the mitochondria, SMAC binds to IAP family proteins displacing them from Caspase:IAP complexes liberating the active caspases.

Literature References
PubMed ID Title Journal Year
15077149 Toxic proteins released from mitochondria in cell death

Saelens, X, Festjens, N, Vande Walle, L, van Gurp, M, van Loo, G, Vandenabeele, P

Oncogene 2004
Participants
Events
Participant Of
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Orthologous Events
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SMAC, XIAP-regulated apoptotic response (Mus musculus)
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SMAC, XIAP-regulated apoptotic response (Schizosaccharomyces pombe)
SMAC, XIAP-regulated apoptotic response (Sus scrofa)
SMAC, XIAP-regulated apoptotic response (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Matthews, L  (2004-08-06)
Reviewed
Vaux, DL  (2019-11-13)
Created
Alnemri, E  (2004-02-17)