Initiation of Nuclear Envelope (NE) Reformation

Stable Identifier
R-HSA-2995383
Type
Pathway
Species
Homo sapiens
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Reassembly of the nuclear envelope (NE) is initiated at late anaphase/early telophase when BANF1 (BAF), which is dispersed throughout the cytoplasm during metaphase, accumulates on the surfaces of coalesced chromosomes. This is coordinated with the chromatin association of membranes and inner nuclear membrane proteins that include EMD (emerin), TMPO (LAP2beta), LEMD3 (MAN1) and LEMD2 (LEM2), and lamins (Haraguchi et al. 2008, reviewed by Wandke and Kutay 2013). The DNA-cross-bridging activity of BANF1 is required for individual chromosomes to properly coalesce for enclosure in a single nucleus (Samwer et al. 2017).

Literature References
PubMed ID Title Journal Year
18628300 Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly

Haraguchi, T, Kojidani, T, Koujin, T, Shimi, T, Osakada, H, Mori, C, Yamamoto, A, Hiraoka, Y

J. Cell. Sci. 2008
23498932 Enclosing chromatin: reassembly of the nucleus after open mitosis

Wandke, C, Kutay, U

Cell 2013
28841419 DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes

Samwer, M, Schneider, MWG, Hoefler, R, Schmalhorst, PS, Jude, JG, Zuber, J, Gerlich, DW

Cell 2017
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