EGR2 and SREBF2 dimer bind SCD5 gene

Stable Identifier
R-HSA-9621400
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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EGR2 and SREBF2 dimer bind SCD5 gene
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SCD5 expression is upregulated during Schwann cell myelination in an EGR2- and SREBF2 dependent manner (LeBlanc et all, 2005; Jang et al, 2010). SCD5 encodes a stearyl-CoA desaturase involved in long chain fatty acid biosynthesis (Wang et al, 2005; Zhang et al, 2005).

Literature References
PubMed ID Title Journal Year
15907797 Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates

Wang, J, Yu, L, Schmidt, RE, Su, C, Huang, X, Gould, K, Cao, G

Biochem. Biophys. Res. Commun. 2005
15610069 Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells

Zhang, S, Yang, Y, Shi, Y

Biochem. J. 2005
21044070 Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes

Jang, SW, Srinivasan, R, Jones, EA, Sun, G, Keles, S, Krueger, C, Chang, LW, Nagarajan, R, Svaren, J

J. Neurochem. 2010
15836632 Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

Leblanc, SE, Srinivasan, R, Ferri, C, Mager, GM, Gillian-Daniel, AL, Wrabetz, L, Svaren, J

J. Neurochem. 2005
Participants
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Output
Participant Of
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Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-26)