Reactome | SCD5 gene expression

SCD5 gene expression

Stable Identifier

R-HSA-9621399

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, endoplasmic reticulum membrane

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Stearoyl-CoA desaturase 5 (SCD5, also known as acyl-CoA desaturase 4 or SCD2) is a ER-membrane protein involved in the desturation of fatty acyl-CoA substrates (Wang et al, 2005; Zhang et al, 2005). SCD5 gene expression is upregulated in an SREBF2- and EGR2-dependent manner during Schwann cell myelination (Tabor et al, 1998; Tabor et al, 1999; Horton et al, 2003; LeBlanc et al, 2004; Jang et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
15610069	Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells Zhang, S, Yang, Y, Shi, Y	Biochem. J.	2005
10400691	Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2 Tabor, DE, Kim, JB, Spiegelman, BM, Edwards, PA	J Biol Chem	1999
9705348	Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1 Tabor, DE, Kim, JB, Spiegelman, BM, Edwards, PA	J. Biol. Chem.	1998
21044070	Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes Jang, SW, Srinivasan, R, Jones, EA, Sun, G, Keles, S, Krueger, C, Chang, LW, Nagarajan, R, Svaren, J	J. Neurochem.	2010
15907797	Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates Wang, J, Yu, L, Schmidt, RE, Su, C, Huang, X, Gould, K, Cao, G	Biochem. Biophys. Res. Commun.	2005
15836632	Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination Leblanc, SE, Srinivasan, R, Ferri, C, Mager, GM, Gillian-Daniel, AL, Wrabetz, L, Svaren, J	J. Neurochem.	2005
14512514	Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes Horton, JD, Shah, NA, Warrington, JA, Anderson, NN, Park, SW, Brown, MS, Goldstein, JL	Proc. Natl. Acad. Sci. U.S.A.	2003