SCD5 gene expression

Stable Identifier
R-HSA-9621399
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
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SCD5 gene expression
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Stearoyl-CoA desaturase 5 (SCD5, also known as acyl-CoA desaturase 4 or SCD2) is a ER-membrane protein involved in the desturation of fatty acyl-CoA substrates (Wang et al, 2005; Zhang et al, 2005). SCD5 gene expression is upregulated in an SREBF2- and EGR2-dependent manner during Schwann cell myelination (Tabor et al, 1998; Tabor et al, 1999; Horton et al, 2003; LeBlanc et al, 2004; Jang et al, 2010).

Literature References
PubMed ID Title Journal Year
10400691 Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2

Spiegelman, BM, Edwards, PA, Tabor, DE, Kim, JB

J Biol Chem 1999
15610069 Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells

Shi, Y, Yang, Y, Zhang, S

Biochem. J. 2005
9705348 Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1

Edwards, PA, Spiegelman, BM, Tabor, DE, Kim, JB

J. Biol. Chem. 1998
21044070 Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes

Nagarajan, R, Keles, S, Jones, EA, Sun, G, Chang, LW, Svaren, J, Jang, SW, Srinivasan, R, Krueger, C

J. Neurochem. 2010
15907797 Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates

Cao, G, Wang, J, Su, C, Yu, L, Huang, X, Schmidt, RE, Gould, K

Biochem. Biophys. Res. Commun. 2005
15836632 Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

Wrabetz, L, Gillian-Daniel, AL, Mager, GM, Ferri, C, Svaren, J, Leblanc, SE, Srinivasan, R

J. Neurochem. 2005
14512514 Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

Shah, NA, Goldstein, JL, Horton, JD, Anderson, NN, Warrington, JA, Brown, MS, Park, SW

Proc. Natl. Acad. Sci. U.S.A. 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SCD5 gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
Active Unit
SREBF2 dimer [nucleoplasm]
EGR2 [nucleoplasm]
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-26)
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