Reactome | HMGCR [endoplasmic reticulum membrane]

HMGCR [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9621345

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMDH_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P04035 HMGCR

Gene Names

HMGCR

Chain

chain:1-888

Reference Genes

BioGPS Gene:3156 HMGCR

COSMIC - genes:HMGCR HMGCR

CTD Gene:3156 HMGCR

dbSNP Gene:3156 HMGCR

ENSEMBL:ENSG00000113161 HMGCR

HGNC:5006 HMGCR

KEGG:hsa:3156 HMGCR

Monarch:3156 HMGCR

NCBI Gene:3156 HMGCR

OMIM:142910 HMGCR

UCSC:P04035 HMGCR

Reference Transcript

Participates

as an output of

HMGCR gene expression (Homo sapiens)

Cross References

RefSeq

XP_054208459.1, XP_011541660.1, NP_001124468.1, XP_054208460.1, NP_000850.1, XP_011541659.1, NP_001351116.1

ZINC - World Drugs

HMDH_HUMAN

Guide to Pharmacology - Targets

639

OpenTargets

ENSG00000113161

ENSEMBL

ENST00000511206, ENST00000343975, ENST00000287936, ENST00000681271, ENSG00000113161, ENST00000681410, ENSP00000287936, ENSP00000426745, ENST00000680940, ENSP00000505805, ENSP00000340816, ENSP00000506232, ENSP00000505561

ZINC - FDA approved

HMDH_HUMAN

ZINC - Substances

HMDH_HUMAN

ZINC - Biogenic

HMDH_HUMAN

ZINC target

P04035

PRO

P04035

GlyGen

P04035

PDB

1DQA, 2R4F, 3CD7, 3CCT, 3CD5, 2Q6C, 1HWK, 3CDB, 1HWL, 3CDA, 3CCW, 3BGL, 1HWI, 1DQ9, 1HW9, 2Q1L, 1HW8, 8S6B, 3CD0, 2Q6B, 3CCZ, 1DQ8, 8PKN, 1HWJ

ZINC - Metabolites

HMDH_HUMAN

HPA

ENSG00000113161-HMGCR

GeneCards

HMGCR

Pharos - Targets

P04035

ZINC - Predictions - Purchasable

HMDH_HUMAN

HMDB Protein

HMDBP00910

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.621	4
UniProt:Q86VZ1 P2RY8			0.527	2
UniProt:Q13304 GPR17	1	GPR17 [plasma membrane] (R-HSA-416429)	0.527	2
UniProt:P54709 ATP1B3	1	ATP1B3 [plasma membrane] (R-HSA-375073)	0.527	3
UniProt:O14967 CLGN			0.527	2
UniProt:Q7Z5B4 RIC3			0.527	2
UniProt:P51684 CCR6	1	CCR6 [plasma membrane] (R-HSA-373089)	0.527	2
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.527	2

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