EGR1 binds the TF gene

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R-HSA-9621035
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Reaction
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Homo sapiens
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EGR1 binds to the promoter of the TF gene to induce transcription downstream of NGF, serum and PMA (Cui et al, 1996; Mullenbrock et al, 2011; Adams et al, 2017). TF encodes Tissue Factor F3, a key initiator of blood clotting (reviewed in Smith et al, 2015).

Literature References
PubMed ID Title Journal Year
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S

PLoS ONE 2017
26018600 How it all starts: Initiation of the clotting cascade

Travers, RJ, Smith, SA, Morrissey, JH

Crit. Rev. Biochem. Mol. Biol. 2015
8576248 Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1

Smith, M, Huang, RP, Oeth, P, Mackman, N, Parry, GC, Adamson, ED, Larson, H, Cui, MZ

J. Biol. Chem. 1996
22065583 Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation

Cooper, GM, Mullenbrock, S, Shah, J

J. Biol. Chem. 2011
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