EGR1 binds the TF gene

Stable Identifier
R-HSA-9621035
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EGR1 binds the TF gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
EGR1 binds to the promoter of the TF gene to induce transcription downstream of NGF, serum and PMA (Cui et al, 1996; Mullenbrock et al, 2011; Adams et al, 2017). TF encodes Tissue Factor F3, a key initiator of blood clotting (reviewed in Smith et al, 2015).
Literature References
PubMed ID Title Journal Year
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Adams, KW, Kletsov, S, Lamm, RJ, Elman, JS, Mullenbrock, S, Cooper, GM

PLoS ONE 2017
26018600 How it all starts: Initiation of the clotting cascade

Smith, SA, Travers, RJ, Morrissey, JH

Crit. Rev. Biochem. Mol. Biol. 2015
8576248 Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1

Cui, MZ, Parry, GC, Oeth, P, Larson, H, Smith, M, Huang, RP, Adamson, ED, Mackman, N

J. Biol. Chem. 1996
22065583 Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation

Mullenbrock, S, Shah, J, Cooper, GM

J. Biol. Chem. 2011
Participants
Input
Output
Participates
as an event of
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-26)
Cite Us!