EGR1 binds the TPH1 promoter

Stable Identifier
R-HSA-9621032
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EGR1 binds the TPH1 promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
EGR1 binds to the TPH1 promoter as assessed by ChIP and electrophoretic mobility shift assay (EMSA) (Adams et al, 2017; Grasberger et al, 2013). EGR1 binding stimulates NGF-dependent signaling (Mullenbrock et al, 2011; Adams et al, 2017).
Literature References
PubMed ID Title Journal Year
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Adams, KW, Kletsov, S, Lamm, RJ, Elman, JS, Mullenbrock, S, Cooper, GM

PLoS ONE 2017
24060757 Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes

Grasberger, H, Chang, L, Shih, W, Presson, AP, Sayuk, GS, Newberry, RD, Karagiannides, I, Pothoulakis, C, Mayer, E, Merchant, JL

Am. J. Gastroenterol. 2013
22065583 Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation

Mullenbrock, S, Shah, J, Cooper, GM

J. Biol. Chem. 2011
Participants
Input
Output
Participates
as an event of
Inferred From
Egr1 binds the Tph1 promoter (Rattus norvegicus)
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-26)
Cite Us!