EGR1 binds the TPH1 promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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EGR1 binds to the TPH1 promoter as assessed by ChIP and electrophoretic mobility shift assay (EMSA) (Adams et al, 2017; Grasberger et al, 2013). EGR1 binding stimulates NGF-dependent signaling (Mullenbrock et al, 2011; Adams et al, 2017).

Literature References
PubMed ID Title Journal Year
24060757 Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes

Grasberger, H, Chang, L, Shih, W, Presson, AP, Sayuk, GS, Newberry, RD, Karagiannides, I, Pothoulakis, C, Mayer, E, Merchant, JL

Am. J. Gastroenterol. 2013
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Adams, KW, Kletsov, S, Lamm, RJ, Elman, JS, Mullenbrock, S, Cooper, GM

PLoS ONE 2017
22065583 Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation

Mullenbrock, S, Shah, J, Cooper, GM

J. Biol. Chem. 2011
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