Reactome | p-CAMKK1 [cytosol]

p-CAMKK1 [cytosol]

Stable Identifier

R-HSA-9619356

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Activated Ca/calmodulin dependent kinase kinase

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        Activation of RAC1 downstream of NMDARs (Homo sapiens)
        
        CaMKK autophosphorylates in the cytosol (Homo sapiens)
        
        p-CaMKK:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-CaMKK [cytosol] (Homo sapiens)
        
        p-CAMKK1 [cytosol] (Homo sapiens)
        
        CaMKKs phosphorylate CAMK1 (Homo sapiens)
        
        p-CaMKK:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-CaMKK [cytosol] (Homo sapiens)
        
        p-CAMKK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N5S9 CAMKK1

Gene Names

CAMKK1, CAMKKA

Chain

chain:1-505

Reference Genes

BioGPS Gene:84254 CAMKK1

COSMIC (genes):CAMKK1 CAMKK1

CTD Gene:84254 CAMKK1

dbSNP Gene:84254 CAMKK1

ENSEMBL:ENSG00000004660 CAMKK1

ENSEMBL:ENSG00000004660.15 CAMKK1

HGNC:1469 CAMKK1

KEGG Gene (Homo sapiens):84254 CAMKK1

Monarch:84254 CAMKK1

NCBI Gene:84254 CAMKK1

OMIM:611411 CAMKK1

UCSC:Q8N5S9 CAMKK1

Reference Transcript

Other Identifiers

11721581_at

11738175_at

1552768_PM_at

1552768_at

16839853

223460_PM_at

223460_at

3741716

3741717

3741718

3741719

3741720

3741721

3741722

3741723

3741725

3741726

3741733

3741736

3741740

3741741

3741743

3741744

3741750

3741754

3741757

3741758

3741759

3741760

3741762

3741763

3741764

3741767

47098_at

8011480

84254

A_23_P431933

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0005515

GO:0005516

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006468

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0035556

GO:0036211

GO:0043226

GO:0045860

GO:0106310

GO:0140096

HMNXSV003036147

HMNXSV003055169

Hs2.8417.2.S1_3p_at

ILMN_1715372

ILMN_2382705

PH_hs_0000898

TC17001013.hg

g13276654_3p_at

Participates

as a member of

p-CaMKK [cytosol] (Homo sapiens)

Other forms of this molecule

p-CAMKK1 [nucleoplasm]

CAMKK1 [nucleoplasm]

CAMKK1 [cytosol]

Inferred To

phospho-p-CAMKK1 [cytosol] (Bos taurus)

phospho-p-CAMKK1 [cytosol] (Canis familiaris)

phospho-p-CAMKK1 [cytosol] (Mus musculus)

phospho-p-CAMKK1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

XP_016880709.1, NP_757344.2, NP_115670.1, NP_757343.2

ZINC - World Drugs

KKCC1_HUMAN

Guide to Pharmacology - Targets

1956

OpenTargets

ENSG00000004660

ZINC - FDA approved

KKCC1_HUMAN

ZINC - Substances

KKCC1_HUMAN

ZINC target

Q8N5S9

ZINC - Biogenic

KKCC1_HUMAN

PRO

Q8N5S9

PDB

6CCF, 6CD6

ZINC - Investigational

KKCC1_HUMAN

GeneCards

Q8N5S9

HPA

ENSG00000004660-CAMKK1

Ensembl

ENST00000348335, ENST00000158166, ENSP00000323118, ENSG00000004660, ENSP00000158166

Pharos - Targets

Q8N5S9

ZINC - Predictions - Purchasable

KKCC1_HUMAN

HMDB Protein

HMDBP01316

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2