Reactome | p-CAMKK1 [nucleoplasm]

p-CAMKK1 [nucleoplasm]

Stable Identifier

R-HSA-444232

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Activated Ca/calmodulin dependent kinase kinase

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
        
        CaMKK autophosphorylates in the nucleus (Homo sapiens)
        
        p-CaMKK:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
        
        p-CaMKK [nucleoplasm] (Homo sapiens)
        
        p-CAMKK1 [nucleoplasm] (Homo sapiens)
        
        CaMKK phosphorylates CAMK4 (Homo sapiens)
        
        p-CaMKK:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
        
        p-CaMKK [nucleoplasm] (Homo sapiens)
        
        p-CAMKK1 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKK autophosphorylates in the nucleus (Homo sapiens)
        
        p-CaMKK:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
        
        p-CaMKK [nucleoplasm] (Homo sapiens)
        
        p-CAMKK1 [nucleoplasm] (Homo sapiens)
        
        CaMKK phosphorylates CAMK4 (Homo sapiens)
        
        p-CaMKK:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
        
        p-CaMKK [nucleoplasm] (Homo sapiens)
        
        p-CAMKK1 [nucleoplasm] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKK autophosphorylates in the nucleus (Homo sapiens)
        
        p-CaMKK:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
        
        p-CaMKK [nucleoplasm] (Homo sapiens)
        
        p-CAMKK1 [nucleoplasm] (Homo sapiens)
        
        CaMKK phosphorylates CAMK4 (Homo sapiens)
        
        p-CaMKK:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
        
        p-CaMKK [nucleoplasm] (Homo sapiens)
        
        p-CAMKK1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N5S9 CAMKK1

Gene Names

CAMKK1, CAMKKA

Chain

chain:1-505

Reference Genes

BioGPS Gene:84254 CAMKK1

COSMIC (genes):CAMKK1 CAMKK1

CTD Gene:84254 CAMKK1

dbSNP Gene:84254 CAMKK1

ENSEMBL:ENSG00000004660 CAMKK1

ENSEMBL_homo_sapiens_GENE:ENSG00000004660.15 CAMKK1

HGNC:1469 CAMKK1

KEGG Gene (Homo sapiens):84254 CAMKK1

Monarch:84254 CAMKK1

NCBI Gene:84254 CAMKK1

OMIM:611411 CAMKK1

UCSC:Q8N5S9 CAMKK1

Reference Transcript

Other Identifiers

11721581_at

11738175_at

1552768_PM_at

1552768_at

16839853

223460_PM_at

223460_at

3741716

3741717

3741718

3741719

3741720

3741721

3741722

3741723

3741725

3741726

3741733

3741736

3741740

3741741

3741743

3741744

3741750

3741754

3741757

3741758

3741759

3741760

3741762

3741763

3741764

3741767

47098_at

8011480

84254

A_23_P431933

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0005515

GO:0005516

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006468

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0035556

GO:0036211

GO:0043226

GO:0106310

GO:0140096

HMNXSV003036147

HMNXSV003055169

Hs2.8417.2.S1_3p_at

ILMN_1715372

ILMN_2382705

PH_hs_0000898

TC17001013.hg

g13276654_3p_at

Participates

as a member of

p-CaMKK [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CAMKK1 [nucleoplasm]

CAMKK1 [cytosol]

p-CAMKK1 [cytosol]

Inferred To

p-Camkk1 [nucleoplasm] (Rattus norvegicus)

phospho-p-CAMKK1 [nucleoplasm] (Bos taurus)

phospho-p-CAMKK1 [nucleoplasm] (Canis familiaris)

phospho-p-CAMKK1 [nucleoplasm] (Mus musculus)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_757343.2, NP_757344.2, NP_115670.1, XP_016880709.1

ZINC - World Drugs

KKCC1_HUMAN

Guide to Pharmacology - Targets

1956

OpenTargets

ENSG00000004660

ZINC - FDA approved

KKCC1_HUMAN

ZINC - Substances

KKCC1_HUMAN

ZINC - Biogenic

KKCC1_HUMAN

ZINC target

Q8N5S9

PRO

Q8N5S9

PDB

6CCF, 6CD6

ZINC - Investigational

KKCC1_HUMAN

GeneCards

Q8N5S9

HPA

ENSG00000004660-CAMKK1

Ensembl

ENST00000158166, ENSG00000004660, ENSP00000158166, ENSP00000323118, ENST00000348335

Pharos - Targets

Q8N5S9

ZINC - Predictions - Purchasable

KKCC1_HUMAN

HMDB Protein

HMDBP01316

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.564	3
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.527	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	2