CaMKII phosphorylates AMPA receptor

Stable Identifier
R-HSA-9618750
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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CaMKII phosphorylates AMPA receptor
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CaMKII, activated by NMDA receptor-mediated calcium influx, translocates to the postsynaptic density (PSD) by binding to the NMDA receptor and phosphorylates AMPA receptor subunit GluA1 (GRIA1, GluR1) and auxiliary proteins. CaMKII-mediated phosphorylation of AMPA receptors enhances association of AMPA the PSD proteins and increases conductance of AMPA receptors (McGlade-McCulloh et al. 1993, Mammen et al. 1997, Strack et al. 1997, Barria et al. 1997, Tomita et al. 2005, Opazo et al. 2010).

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
calmodulin-dependent protein kinase activity of Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane]
Physical Entity
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane]
Activity
calmodulin-dependent protein kinase activity (0004683)
Inferred From
Camk2 phosphorylates GluA1 (Gria1) (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-11)