CaMKII phosphorylates AMPA receptor

Stable Identifier
R-HSA-9618750
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CaMKII, activated by NMDA receptor-mediated calcium influx, translocates to the postsynaptic density (PSD) by binding to the NMDA receptor and phosphorylates AMPA receptor subunit GluA1 (GRIA1, GluR1) and auxiliary proteins. CaMKII-mediated phosphorylation of AMPA receptors enhances association of AMPA the PSD proteins and increases conductance of AMPA receptors (McGlade-McCulloh et al. 1993, Mammen et al. 1997, Strack et al. 1997, Barria et al. 1997, Tomita et al. 2005, Opazo et al. 2010).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calmodulin-dependent protein kinase activity of Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created