Long-term potentiation

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R-HSA-9620244
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Homo sapiens
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In long-term potentiation (LTP), involved in learning and memory, a brief period of synaptic activity induces a lasting increase in the strength of the synapse. LTP is initiated by NMDA receptor-mediated activation of calcium/calmodulin-dependent protein kinase II (CaMKII), followed by binding of CaMKII to the NMDA receptor and CaMKII-mediated phosphorylation of AMPA receptor subunits (reviewed by Lisman et al. 2012 and Luscher and Malenka 2012).

Literature References
PubMed ID Title Journal Year
22334212 Mechanisms of CaMKII action in long-term potentiation

Lisman, J, Yasuda, R, Raghavachari, S

Nat. Rev. Neurosci. 2012
22510460 NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD)

Malenka, RC, L├╝scher, C

Cold Spring Harb Perspect Biol 2012
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