Long-term potentiation

Stable Identifier
R-HSA-9620244
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Long-term potentiation
Click the image above or here to open this pathway in the Pathway Browser

In long-term potentiation (LTP), involved in learning and memory, a brief period of synaptic activity induces a lasting increase in the strength of the synapse. LTP is initiated by NMDA receptor-mediated activation of calcium/calmodulin-dependent protein kinase II (CaMKII), followed by binding of CaMKII to the NMDA receptor and CaMKII-mediated phosphorylation of AMPA receptor subunits (reviewed by Lisman et al. 2012 and Luscher and Malenka 2012).

Literature References
PubMed ID Title Journal Year
22334212 Mechanisms of CaMKII action in long-term potentiation

Lisman, J, Yasuda, R, Raghavachari, S

Nat. Rev. Neurosci. 2012
22510460 NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD)

Malenka, RC, Lüscher, C

Cold Spring Harb Perspect Biol 2012
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
chemical synaptic transmission (0007268)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-21)
Cite Us!