Camk2 phosphorylates GluA1 (Gria1)

Stable Identifier
R-RNO-9620437
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Camk2 phosphorylates GluA1 (Gria1)
Recombinant rat Camk2a phosphorylates recombinant rat GluA1 (Gria1) (McGlade-McCulloh et al. 1993, Barria et al. 1997, Mammen et al. 1997) on serine residue S849 (Mammen et al. 1997).
Literature References
PubMed ID Title Journal Year
8385275 Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II

McGlade-McCulloh, E, Yamamoto, H, Tan, SE, Brickey, DA, Soderling, TR

Nature 1993
9405465 Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II

Mammen, AL, Kameyama, K, Roche, KW, Huganir, RL

J. Biol. Chem. 1997
9197267 Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation

Barria, A, Muller, D, Derkach, V, Griffith, LC, Soderling, TR

Science 1997
Participants
Input
Output
Catalyst Activity

calcium/calmodulin-dependent protein kinase activity of p-T286-Camk2a dodecamer:Calm1:4xCa2+ [cytosol]

Physical Entity
p-T286-Camk2a dodecamer:Calm1:4xCa2+ [cytosol] (Rattus norvegicus)
Activity
calcium/calmodulin-dependent protein kinase activity (GO:0004683)
Orthologous Events
CaMKII phosphorylates AMPA receptor (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-24)
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