The promoter of the CSF3R gene contains 2 binding sites for SPI1 (PU.1) in the 5' untranslated region (Smith et al. 1996). The 3' site binds SPI1 less strongly (Smith et al. 1996). SPI1 and CEBPA appear to act synergistically in activating transcription of CSFR3. Chromatin immunoprecipitation indicates CEBPA and DEK1 together bind the CSF3R promoter and depletion of DEK1 reduces activation of transcription by CEBPA (Koleva et al. 2012).