SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene

Stable Identifier
R-HSA-9617207
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene
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The promoter of the CSF3R gene contains 2 binding sites for SPI1 (PU.1) in the 5' untranslated region (Smith et al. 1996). The 3' site binds SPI1 less strongly (Smith et al. 1996). SPI1 and CEBPA appear to act synergistically in activating transcription of CSFR3. Chromatin immunoprecipitation indicates CEBPA and DEK1 together bind the CSF3R promoter and depletion of DEK1 reduces activation of transcription by CEBPA (Koleva et al. 2012).

Literature References
PubMed ID Title Journal Year
8695841 PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells

Dziennis, SE, Gonzalez, DA, Smith, LT, Tenen, DG, Hohaus, S

Blood 1996
22474248 C/EBPα and DEK coordinately regulate myeloid differentiation

Marto, JA, Webber, JT, Alberta, JA, Carrasco-Alfonso, MJ, Radomska, HS, Marcucci, G, Ficarro, SB, Koleva, RI, Tenen, DG, Luckey, CJ

Blood 2012
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Authored
May, B  (2018-08-16)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2018-08-17)
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