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SPI1 [nucleoplasm]
Stable Identifier
R-HSA-8865503
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PU.1, Transcription factor PU.1, 31 kDa-transforming protein
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA (Homo sapiens)
CEBPA gene:RUNX1:SPI1:GATA2:TAL1:FLI1:MYB [nucleoplasm] (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid (Homo sapiens)
CEBPE gene:EP300:SPI1:PML [nucleoplasm] (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK (Homo sapiens)
CSF3R gene:SPI1:CEPBA dimer:DEK [nucleoplasm] (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)
CEBPA gene:RUNX1:SPI1:GATA2:TAL1:FLI1:MYB [nucleoplasm] (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene (Homo sapiens)
CSF3R gene:SPI1:CEPBA dimer:DEK [nucleoplasm] (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene (Homo sapiens)
CEBPE gene:EP300:SPI1:PML [nucleoplasm] (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (Homo sapiens)
SPI1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17947 SPI1
Gene Names
SPI1
Chain
chain:1-270
Reference Genes
BioGPS Gene:6688 SPI1
COSMIC (genes):SPI1 SPI1
CTD Gene:6688 SPI1
dbSNP Gene:6688 SPI1
ENSEMBL:ENSG00000066336 SPI1
HGNC:11241 SPI1
KEGG:hsa:6688 SPI1
Monarch:6688 SPI1
NCBI Gene:6688 SPI1
OMIM:165170 SPI1
UCSC:P17947 SPI1
Reference Transcript
RefSeq:NM_003120.2 SPI1
RefSeq:NM_001080547.1 SPI1
Other Identifiers
11723165_a_at
1341_at
16738007
16738018
205312_PM_at
205312_at
3372003
3372175
3372176
3372177
3372179
3372180
3372181
3372182
3372183
3372185
3372190
3372191
3372192
3372193
3372200
6688
7947861
A_21_P0014266
A_23_P115998
A_33_P3489646
GE59767
GE84485
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001216
GO:0001217
GO:0002357
GO:0002572
GO:0002573
GO:0003677
GO:0003682
GO:0003700
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0006325
GO:0006355
GO:0006357
GO:0010629
GO:0016020
GO:0030154
GO:0032088
GO:0036462
GO:0042826
GO:0043226
GO:0043314
GO:0043565
GO:0045579
GO:0045646
GO:0045815
GO:0045892
GO:0045944
GO:0051090
GO:0051525
GO:0060090
GO:0061629
GO:0070102
GO:0090402
GO:0097677
GO:0098508
GO:0120186
GO:0140110
GO:0140297
GO:0140311
GO:0140313
GO:1900745
GO:1901223
GO:1902895
GO:1904151
GO:1904178
GO:1904238
GO:1905036
GO:1905453
HMNXSV003006070
HMNXSV003010117
HMNXSV003017604
ILMN_1696463
ILMN_2392043
PH_hs_0009533
PH_hs_0031901
TC11001736.hg
TC11001737.hg
X52056_at
g4507174_3p_at
p2290
Participates
as an input of
SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene (Homo sapiens)
SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene (Homo sapiens)
RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)
as a component of
CSF3R gene:SPI1:CEPBA dimer:DEK [nucleoplasm] (Homo sapiens)
CEBPE gene:EP300:SPI1:PML [nucleoplasm] (Homo sapiens)
CEBPA gene:RUNX1:SPI1:GATA2:TAL1:FLI1:MYB [nucleoplasm] (Homo sapiens)
as an output of
SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (Homo sapiens)
Cross References
OpenTargets
ENSG00000066336
ENSEMBL
ENSG00000066336
,
ENSP00000227163
,
ENSP00000367799
,
ENST00000227163
,
ENST00000378538
HPA
ENSG00000066336-SPI1
GeneCards
SPI1
PRO
P17947
Pharos - Targets
P17947
Orphanet
SPI1
PDB
8EQG
,
8UHK
,
8E4H
,
8EQL
,
8VDI
,
8EE9
,
8EKJ
,
8EMD
,
8UFZ
,
8EQK
,
8EKV
,
8EJ8
,
8EJ6
,
8VDH
,
8UFK
,
8T9U
,
8V9N
,
8EK8
,
8EM9
,
8EK3
,
8UFF
,
8EKU
,
8EKZ
,
8E3K
,
8ENG
,
8EO4
,
8E3R
,
8EBH
,
8E5Y
,
8EO1
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23769 GATA2
1
GATA2 [nucleoplasm]
(R-HSA-996735)
0.639
4
UniProt:Q15156 Q15156
0.537
20
UniProt:P78527 PRKDC
4
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [nucleoplasm]
(R-HSA-62161)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.525
2
UniProt:P31260 HXA10
0.524
2
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