Reactome | SPI1 [nucleoplasm]

SPI1 [nucleoplasm]

Stable Identifier

R-HSA-8865503

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PU.1, Transcription factor PU.1, 31 kDa-transforming protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P17947 SPI1

Gene Names

SPI1

Chain

chain:1-270

Reference Genes

BioGPS Gene:6688 SPI1

COSMIC (genes):SPI1 SPI1

CTD Gene:6688 SPI1

dbSNP Gene:6688 SPI1

ENSEMBL:ENSG00000066336.12 SPI1

HGNC:11241 SPI1

KEGG Gene (Homo sapiens):6688 SPI1

Monarch:6688 SPI1

NCBI Gene:6688 SPI1

OMIM:165170 SPI1

UCSC:P17947 SPI1

Reference Transcript

Other Identifiers

0002030670

11723165_a_at

1341_at

16738007

205312_PM_at

205312_at

3372175

3372176

3372177

3372179

3372180

3372181

3372182

3372183

6688

7947861

A_23_P115998

A_33_P3489646

GE59767

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0000987

GO:0001216

GO:0001217

GO:0001227

GO:0001228

GO:0001944

GO:0002314

GO:0002316

GO:0002320

GO:0002327

GO:0002357

GO:0002376

GO:0002572

GO:0002573

GO:0003677

GO:0003682

GO:0003700

GO:0003723

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0007155

GO:0007179

GO:0010628

GO:0010629

GO:0012501

GO:0016192

GO:0023052

GO:0030098

GO:0030154

GO:0030218

GO:0030225

GO:0030851

GO:0031663

GO:0032088

GO:0032991

GO:0035019

GO:0036211

GO:0036462

GO:0042826

GO:0043011

GO:0043226

GO:0043314

GO:0043565

GO:0043966

GO:0044027

GO:0045347

GO:0045579

GO:0045646

GO:0045814

GO:0045815

GO:0045892

GO:0045893

GO:0045944

GO:0048856

GO:0048870

GO:0051090

GO:0051525

GO:0060033

GO:0060090

GO:0061629

GO:0070102

GO:0090241

GO:0090402

GO:0097677

GO:0098508

GO:0098542

GO:0120186

GO:0140297

GO:0140311

GO:0140313

GO:1900745

GO:1901223

GO:1901674

GO:1902262

GO:1902895

GO:1904151

GO:1904178

GO:1904238

GO:1905036

GO:1905453

GO:2000529

HMNXSV003017604

ILMN_1696463

ILMN_2392043

PH_hs_0009533

PH_hs_0031901

TC11001736.hg

X52056_at

g4507174_3p_at

Participates

as an input of

as a component of

as an output of

SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (Homo sapiens)

Cross References

RefSeq

NP_003111.2, NP_001074016.1

OpenTargets

ENSG00000066336

GeneCards

P17947

HPA

ENSG00000066336-SPI1

Ensembl

ENST00000227163, ENSG00000066336, ENSP00000367799, ENSP00000227163, ENST00000378538

PRO

P17947

Pharos - Targets

P17947

Orphanet

29688

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23769 GATA2	1	GATA2 [nucleoplasm] (R-HSA-996735)	0.639	4
UniProt:Q15156 Q15156			0.537	20
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302)	0.525	2
UniProt:P31260 HXA10			0.524	2