SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene

Stable Identifier
R-HSA-9617064
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene
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SPI1 (PU.1) binds the promoter of the CEBPE gene. PML (isoform 4) interacts with SPI1 and recruits the coactivator EP300 (p300) to SPI1 (Yoshida et al. 2007). The PML-RARA leukemogenic fusion protein dissociates the SPI1:PML:EP300 complex and inhibits transcription of CEBPE, thereby interfering with granulocyte differentiation (Yoshida et al. 2007).
Literature References
PubMed ID Title Journal Year
17562868 PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation

Yoshida, H, Ichikawa, H, Tagata, Y, Katsumoto, T, Ohnishi, K, Akao, Y, Naoe, T, Pandolfi, PP, Kitabayashi, I

Mol. Cell. Biol. 2007
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Authored
May, B  (2018-08-15)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2018-08-16)
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