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HSPA8 binds substrate
Stable Identifier
R-HSA-9615721
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Autophagy (Homo sapiens)
Chaperone Mediated Autophagy (Homo sapiens)
HSPA8 binds substrate (Homo sapiens)
Late endosomal microautophagy (Homo sapiens)
HSPA8 binds substrate (Homo sapiens)
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Intracellular proteins are targeted for proteolytic degradation in the lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) acts as the constitutive chaperone that binds substrate proteins in the cytosol. HSPA8 recognizes a motif based on the charge of the amino acids (Chiang H et al. 1989, Dice JF et al. 1990). This allows the motif to have multiple sequence possibilities and also create a motif through post-translational modifications such as phosphorylation and acetylation. Once bound with HSPA8, the substrates are targeted to the lysosome or endosome.
Literature References
PubMed ID
Title
Journal
Year
2799391
A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins
Dice, JF
,
Plant, CP
,
Terlecky, SR
,
Chiang, HL
Science
1989
25961502
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
Cuervo, AM
,
Kaushik, S
Nat. Cell Biol.
2015
2204156
Peptide sequences that target cytosolic proteins for lysosomal proteolysis
Dice, JF
Trends Biochem. Sci.
1990
Participants
Input
HSPA8 [cytosol]
(Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol]
(Homo sapiens)
Output
HSPA8 bound autophagic substrates [cytosol]
(Homo sapiens)
Participates
as an event of
Late endosomal microautophagy (Homo sapiens)
Chaperone Mediated Autophagy (Homo sapiens)
Inferred From
Hspa8 binds Rnase1 (Rattus norvegicus)
Authored
Varusai, TM (2019-02-21)
Reviewed
Metzakopian, E (2019-02-22)
Created
Varusai, TM (2018-08-08)
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