Hspa8 binds Rnase1

Stable Identifier
R-RNO-9615712
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hspa8 binds Rnase1
Intracellular proteins are targeted for proteolytic degradation in the lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (Hspa8) acts as the constitutive chaperone that binds Ribonuclease pancreatic beta-type (Rnase1) in the cytosol. Hspa8 recognizes a motif on Rnase1 based on the charge of amino acids (Chiang H et al. 1989). Once bound with Hspa8, the substrates are targeted to the lysosome or endosome.
Literature References
PubMed ID Title Journal Year
2799391 A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

Chiang, HL, Terlecky, SR, Plant, CP, Dice, JF

Science 1989
Participants
Input
Output
Orthologous Events
HSPA8 binds substrate (Homo sapiens)
Authored
Varusai, TM  (2019-11-08)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-08-08)
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