Chaperone Mediated Autophagy

Stable Identifier
R-HSA-9613829
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

In contrary to the vesicle-mediated macroautophagy, the chaperone mediated mechanism of autophagy selectively targets individual proteins to the lysosome for degradation. Chaperones bind intracellular proteins based on recognition motifs and transports them from the cytosol to the lysosomal membrane. Subsequently, the protein is translocated into the lumen for digestion (Cuervo A M et al. 2014, Kaushik S et al. 2018).

Literature References
PubMed ID Title Journal Year
24281265 Chaperone-mediated autophagy: roles in disease and aging

Cuervo, AM, Wong, E

Cell Res. 2014
Participants
Participant Of
hasEvent
Event Information
Cross References
BioModels Database
Authored
Reviewed
Created