Myelin basic protein (MBP) is a key component in the myelin sheath that coats axons of the peripheral nervous system. MBP expression is regulated by EGR2 binding to sites in an enhancer that lies ~9kb upstream of the transcriptional start site, as well as to a binding site in the first intron (Forgahni et al, 2001; Denarier et al, 2005; Jang et al, 2006; Jones et al, 2007). Based on conservation of binding sites, SOX10 is predicted to also contribute to MBP expression during myelination (Jones et al, 2007), and this is substantiated by ChIP seq analysis and Sox10 knockdown studies in mouse (Arido-Lopez et al, 2015).
Jones, EA, Jang, SW, Mager, GM, Chang, LW, Srinivasan, R, Gokey, NG, Ward, RM, Nagarajan, R, Svaren, J
Lopez-Anido, C, Sun, G, Koenning, M, Srinivasan, R, Hung, HA, Emery, B, Keles, S, Svaren, J
Jang, SW, Leblanc, SE, Roopra, A, Wrabetz, L, Svaren, J
Denarier, E, Forghani, R, Farhadi, HF, Dib, S, Dionne, N, Friedman, HC, Lepage, P, Hudson, TJ, Drouin, R, Peterson, A
Forghani, R, Garofalo, L, Foran, DR, Farhadi, HF, Lepage, P, Hudson, TJ, Tretjakoff, I, Valera, P, Peterson, A
© 2021 Reactome
