EGR2 and SOX10 bind the MBP gene

Stable Identifier
R-HSA-9615638
Type
Reaction [binding]
Species
Homo sapiens
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Myelin basic protein (MBP) is a key component in the myelin sheath that coats axons of the peripheral nervous system. MBP expression is regulated by EGR2 binding to sites in an enhancer that lies ~9kb upstream of the transcriptional start site, as well as to a binding site in the first intron (Forgahni et al, 2001; Denarier et al, 2005; Jang et al, 2006; Jones et al, 2007). Based on conservation of binding sites, SOX10 is predicted to also contribute to MBP expression during myelination (Jones et al, 2007), and this is substantiated by ChIP seq analysis and Sox10 knockdown studies in mouse (Arido-Lopez et al, 2015).

Literature References
PubMed ID Title Journal Year
18634568 Interactions of Sox10 and Egr2 in myelin gene regulation

Jones, EA, Jang, SW, Mager, GM, Chang, LW, Srinivasan, R, Gokey, NG, Ward, RM, Nagarajan, R, Svaren, J

Neuron Glia Biol. 2007
25974668 Differential Sox10 genomic occupancy in myelinating glia

Lopez-Anido, C, Sun, G, Koenning, M, Srinivasan, R, Hung, HA, Emery, B, Keles, S, Svaren, J

Glia 2015
16923174 In vivo detection of Egr2 binding to target genes during peripheral nerve myelination

Jang, SW, Leblanc, SE, Roopra, A, Wrabetz, L, Svaren, J

J. Neurochem. 2006
16319321 Functional organization of a Schwann cell enhancer

Denarier, E, Forghani, R, Farhadi, HF, Dib, S, Dionne, N, Friedman, HC, Lepage, P, Hudson, TJ, Drouin, R, Peterson, A

J. Neurosci. 2005
11356866 A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming schwann cells

Forghani, R, Garofalo, L, Foran, DR, Farhadi, HF, Lepage, P, Hudson, TJ, Tretjakoff, I, Valera, P, Peterson, A

J. Neurosci. 2001
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