Reactome | EGR2 and SOX10 bind the MBP gene

EGR2 and SOX10 bind the MBP gene

Stable Identifier

R-HSA-9615638

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Myelin basic protein (MBP) is a key component in the myelin sheath that coats axons of the peripheral nervous system. MBP expression is regulated by EGR2 binding to sites in an enhancer that lies ~9kb upstream of the transcriptional start site, as well as to a binding site in the first intron (Forgahni et al, 2001; Denarier et al, 2005; Jang et al, 2006; Jones et al, 2007). Based on conservation of binding sites, SOX10 is predicted to also contribute to MBP expression during myelination (Jones et al, 2007), and this is substantiated by ChIP seq analysis and Sox10 knockdown studies in mouse (Arido-Lopez et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
25974668	Differential Sox10 genomic occupancy in myelinating glia Lopez-Anido, C, Sun, G, Koenning, M, Srinivasan, R, Hung, HA, Emery, B, Keles, S, Svaren, J	Glia	2015
18634568	Interactions of Sox10 and Egr2 in myelin gene regulation Jones, EA, Jang, SW, Mager, GM, Chang, LW, Srinivasan, R, Gokey, NG, Ward, RM, Nagarajan, R, Svaren, J	Neuron Glia Biol.	2007
16923174	In vivo detection of Egr2 binding to target genes during peripheral nerve myelination Jang, SW, Leblanc, SE, Roopra, A, Wrabetz, L, Svaren, J	J. Neurochem.	2006
16319321	Functional organization of a Schwann cell enhancer Denarier, E, Forghani, R, Farhadi, HF, Dib, S, Dionne, N, Friedman, HC, Lepage, P, Hudson, TJ, Drouin, R, Peterson, A	J. Neurosci.	2005
11356866	A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming schwann cells Forghani, R, Garofalo, L, Foran, DR, Farhadi, HF, Lepage, P, Hudson, TJ, Tretjakoff, I, Valera, P, Peterson, A	J. Neurosci.	2001