EGR-dependent NAB2 gene expression

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R-HSA-9612493
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Reaction [omitted]
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Homo sapiens
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NAB1 and 2 (NGFI-A binding protein) are transcriptional co-factors that interact with EGR1, 2 and 3 and repress or activate transcription of EGR target genes in a context dependent fashion (Swirnoff et al, 1998; Svaren et al, 1996; Svaren et al, 1998; Russo et al, 1995; Sevetson et al, 2000; Abdulkadir et al, 2001; Le et al, 2005). NAB proteins may contribute to transcriptional repression through the recruitment of CHD4 (Srinivasan et al, 2006).
NAB2 is a delayed immediate early gene that is expressed in response to many of the same stimuli as EGR (Qu et al, 1998). Expression of NAB2 is regulated in part by the binding of EGR proteins to the cognate site in the NAB2 promoter (Kumbrink et al, 2005; Kumbrink et al, 2010). NAB2 expression is in frequently lost in prostate carcinomas and EGR1 is frequently overexpressed (Abdulkadir et al, 2001; Eid et al, 1998; Thigpen et al, 1996).

Literature References
PubMed ID Title Journal Year
9418898 Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain

Swirnoff, AH, Apel, ED, Svaren, J, Sevetson, BR, Zimonjic, DB, Popescu, NC, Milbrandt, J

Mol. Cell. Biol. 1998
16136673 Nab proteins are essential for peripheral nervous system myelination

Le, N, Nagarajan, R, Wang, JY, Svaren, J, LaPash, C, Araki, T, Schmidt, RE, Milbrandt, J

Nat. Neurosci. 2005
9722618 The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells

Qu, Z, Wolfraim, LA, Svaren, J, Ehrengruber, MU, Davidson, N, Milbrandt, J

J. Cell Biol. 1998
16574654 NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex

Srinivasan, R, Mager, GM, Ward, RM, Mayer, J, Svaren, J

J. Biol. Chem. 2006
11567222 Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma

Abdulkadir, SA, Carbone, JM, Naughton, CK, Humphrey, PA, Catalona, WJ, Milbrandt, J

Hum. Pathol. 2001
8668170 NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

Svaren, J, Sevetson, BR, Apel, ED, Zimonjic, DB, Popescu, NC, Milbrandt, J

Mol. Cell. Biol. 1996
9622090 Expression of early growth response genes in human prostate cancer

Eid, MA, Kumar, MV, Iczkowski, KA, Bostwick, DG, Tindall, DJ

Cancer Res. 1998
16260776 Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop

Kumbrink, J, Gerlinger, M, Johnson, JP

J. Biol. Chem. 2005
7624335 Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription

Russo, MW, Sevetson, BR, Milbrandt, J

Proc. Natl. Acad. Sci. U.S.A. 1995
9774344 Novel mutants of NAB corepressors enhance activation by Egr transactivators

Svaren, J, Sevetson, BR, Golda, T, Stanton, JJ, Swirnoff, AH, Milbrandt, J

EMBO J. 1998
8583621 Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma

Thigpen, AE, Cala, KM, Guileyardo, JM, Molberg, KH, McConnell, JD, Russell, DW

J. Urol. 1996
20506119 EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin

Kumbrink, J, Kirsch, KH, Johnson, JP

J. Cell. Biochem. 2010
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