GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17

Stable Identifier
R-HSA-9610408
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GluN1:GluN2B (GRIN1:GRIN2B) di-heteromers are transported to the plasma membrane from the endoplasmic reticulum (ER) via transport vesicles. At the membrane of transport vesicles, GluN1:GluN2B NMDA receptors associate with the complex of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1. The microtubule-associated kinesin motor protein KIF17 binds to the LIN7:CASK:APBA1 complex (Jo et al. 1999, Setou et al. 2000). During transport from ER to the plasma membrane, NMDA receptors are diverted from the somatic Golgi network and go through the dendritic ER subcompartment and dendritic Golgi instead. Besides CASK, interaction with DLG1 (SAP97) is required for GluN1:GluN2B NMDA receptors to go through this transport route (Jeyifous et al. 2009).

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