GluN1:GluN2B (Grin1:Grin2b) di-heterotetramers bind Dlg1 and Cask

Stable Identifier
R-RNO-9610612
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GluN1:GluN2B (Grin1:Grin2b) di-heterotetramers bind Dlg1 and Cask
In rat neurons, during transport from the endoplasmic reticulum (ER) to the plasma membrane, the interaction of GluN1:GluN2B (Grin1:Grin2b) NMDA receptors with Dlg1 (Sap97) and Cask diverts NMDA receptors from the somatic Golgi network and directs them through the dendritic ER subcompartment and dendritic Golgi instead (Jeyifous et al. 2009).
Literature References
PubMed ID Title Journal Year
19620977 SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway

Lin, EI, Montgomery, JM, Marshall, J, Waites, CL, de Silva, T, Schubert, M, Specht, CG, Garner, CC, Green, WN, Jeyifous, O, Aoki, C, Fujisawa, S

Nat. Neurosci. 2009
Participants
Input
Output
Orthologous Events
GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17 (Homo sapiens)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Traynelis, SF  (2019-02-11)
Camp, C  (2019-02-11)
Bhattacharya, S  (2019-02-11)
Created
Orlic-Milacic, M  (2018-06-11)
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