Reactome | GluN1:GluN2B (Grin1:Grin2b) di-heterotetramers bind Lin7:Cask:Apba1 and Kif17

GluN1:GluN2B (Grin1:Grin2b) di-heterotetramers bind Lin7:Cask:Apba1 and Kif17

Stable Identifier

R-MMU-9610428

Type

Reaction [binding]

Species

Mus musculus

Compartment

cytosol, endoplasmic reticulum membrane, transport vesicle membrane

ReviewStatus

5/5

General

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GluN1:GluN2B (Grin1:Grin2b) di-heterotetramers bind Lin7:Cask:Apba1 and Kif17

In mouse neurons, GluN1:GluN2B (Grin1:Grin2b) di-heteromers are transported to the plasma membrane from the endoplasmic reticulum (ER) via transport vesicles. At the membrane of transport vesicles, GluN1:GluN2b NMDA receptors associate with the complex of Lin7 (Lin7a, Lin7b or Lin7c), Cask and Apba1. The microtubule-associated kinesin motor protein Kif17 binds to the Lin7:Cask:Apba1 complex (Jo et al. 1999, Setou et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10341223	Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex Derin, R, Jo, K, Bredt, DS, Li, M	J. Neurosci.	1999
10846156	Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport Seog, DH, Setou, M, Nakagawa, T, Hirokawa, N	Science	2000

Participants

Input

Output

Grin1:Grin2b di-heterotetramer:Lin7:Cask:Apba1:Kif17:microtubule [transport vesicle membrane] (Mus musculus)

Orthologous Events

GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17 (Homo sapiens)

Authored

Orlic-Milacic, M (2019-01-05)

Reviewed

Traynelis, SF (2019-02-11)

Camp, C (2019-02-11)

Bhattacharya, S (2019-02-11)

Created

Orlic-Milacic, M (2018-06-09)

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