Reactome | p-CD19:VAV binds PI3K and GRB2

p-CD19:VAV binds PI3K and GRB2

Stable Identifier

R-HSA-9606887

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane

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Phosphorylated CD19 binds PI3K (Roifman and Ke 1993, Chalupny et al. 1993, Uckun et al. 1993, Weng et al. 1994, Brooks et al. 2000, Brooks et al. 2004) and can bind PLC-gamma2 (PLCG2), which competes with VAV1 for the binding to phosphotyrosine-391 on CD19 (Brooks et al. 2000, Brooks et al. 2004). GRB2 appears to bind phosphotyrosine-330 on CD19 (Brooks et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
7528218	Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors LeBien, TW, Jarvis, L, Weng, WK	J Biol Chem	1994
7691807	Signal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny Stealey, B, Bolen, JB, Dibirdik, I, Jarvis, L, Jun, X, Uckun, FM, Myers, DE, Burkhardt, AL, Tuel-Ahlgren, L	J Biol Chem	1993
7687539	Tyrosine phosphorylation of CD19 in pre-B and mature B cells Kanner, SB, Wee, SF, Gilliland, LK, Schieven, GL, Aruffo, A, Ledbetter, JA, Chalupny, NJ	EMBO J	1993
7687428	CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells Ke, S, Roifman, CM	Biochem Biophys Res Commun	1993
10706702	Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines Li, X, Volanakis, EJ, Carter, RH, Brooks, SR	J Immunol	2000
15187135	Binding of cytoplasmic proteins to the CD19 intracellular domain is high affinity, competitive, and multimeric Freeberg, L, Carter, RH, Kirkham, PM, Brooks, SR	J Immunol	2004