Reactome | CD19 Signalosome [plasma membrane]

CD19 Signalosome [plasma membrane]

Stable Identifier

R-HSA-2076233

Type

Complex

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD19 Signalosome [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD19 Signalosome [plasma membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
7528218	Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors Weng, WK, Jarvis, L, LeBien, TW	J Biol Chem	1994
10706702	Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines Brooks, SR, Li, X, Volanakis, EJ, Carter, RH	J Immunol	2000
15187135	Binding of cytoplasmic proteins to the CD19 intracellular domain is high affinity, competitive, and multimeric Brooks, SR, Kirkham, PM, Freeberg, L, Carter, RH	J Immunol	2004

Participants

components

Participates

as an output of

p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)

as a member of

Activator:PI3K [plasma membrane] (Homo sapiens)

Inferred To

CD19 Signalosome [plasma membrane] (Bos taurus)

CD19 Signalosome [plasma membrane] (Canis familiaris)

CD19 Signalosome [plasma membrane] (Drosophila melanogaster)

CD19 Signalosome [plasma membrane] (Gallus gallus)

CD19 Signalosome [plasma membrane] (Mus musculus)

CD19 Signalosome [plasma membrane] (Rattus norvegicus)

CD19 Signalosome [plasma membrane] (Sus scrofa)

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