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TRAF6:hp-IRAK1:Pellino
Stable Identifier
R-HSA-937020
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-Like Receptors Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
IRAK1 phosphorylates Pellino (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:Mal cascade initiated on plasma membrane (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
IRAK1 phosphorylates Pellino (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:Mal cascade initiated on plasma membrane (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
IRAK1 phosphorylates Pellino (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:Mal cascade initiated on plasma membrane (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
IRAK1 phosphorylates Pellino (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
IRAK1 phosphorylates Pellino (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17675297
Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases
J Biol Chem
2007
Participants
components
p-Pellino-1,2,(3) [cytosol] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
Participant Of
input
IRAK1 phosphorylates Pellino
output
Pellino binds hp-IRAK1:TRAF6
Inferred To
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Bos taurus)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Caenorhabditis elegans)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Canis familiaris)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Danio rerio)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Drosophila melanogaster)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Mus musculus)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Rattus norvegicus)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Sus scrofa)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Xenopus tropicalis)
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