Activated TRAF6 synthesizes unanchored polyubiquitin chains

Stable Identifier
R-HSA-936986
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activated TRAF6 synthesizes unanchored polyubiquitin chains
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Polyubiquitinated TRAF6 (as E3 ubiquitin ligase) generates free K63 -linked polyubiquitin chains that non-covalently associate with ubiquitin receptors of TAB2/TAB3 regulatory proteins of the TAK1 complex, leading to the activation of the TAK1 kinase.
Literature References
PubMed ID Title Journal Year
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Xia, ZP, Sun, L, Chen, X, Pineda, G, Jiang, X, Adhikari, A, Zeng, W, Chen, ZJ

Nature 2009
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Catalyst Activity

ubiquitin-protein transferase activity of p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane]

Physical Entity
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Canis familiaris)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Drosophila melanogaster)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Sus scrofa)
Authored
Shamovsky, V  (2010-06-01)
Reviewed
Gillespie, ME  (2010-11-30)
Napetschnig, J  (2012-11-16)
Fitzgerald, KA  (2012-11-13)
Created
Shamovsky, V  (2010-08-25)
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