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UBA7
Stable Identifier
R-HSA-936550
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UBE1L, Ubiquitin-like modifier-activating enzyme 7, UBA7_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
E1 mediated ubiquitin activation (Homo sapiens)
E1 bound ubiquitin [cytosol] (Homo sapiens)
Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Transfer of ubiquitin from E1 to E2 (Homo sapiens)
E1 bound ubiquitin [cytosol] (Homo sapiens)
Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)
ISG15:UBA7 [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)
ISG15:UBA7 [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
ISGylation of DDX58 (Homo sapiens)
ISG15:DDX58 conjugate [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
E2 enzymes UbcH8/UBE1L [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
E2 enzymes UbcH8/UBE1L [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
viral dsRNA binds DDX58 (Homo sapiens)
ISG15:DDX58 conjugate [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
E2 enzymes UbcH8/UBE1L [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41226 UBA7
Gene Names
UBA7, UBE1L, UBE2
Chain
chain:1-1012
Reference Genes
BioGPS Gene:7318 UBA7
COSMIC (genes):UBA7 UBA7
CTD Gene:7318 UBA7
dbSNP Gene:7318 UBA7
ENSEMBL:ENSG00000182179 UBA7
HGNC:12471 UBA7
KEGG Gene (Homo sapiens):hsa:7318 UBA7
Monarch:7318 UBA7
NCBI Gene:7318 UBA7
OMIM:191325 UBA7
UCSC:P41226 UBA7
Reference Transcript
RefSeq:NM_003335.2 UBA7
Other Identifiers
0001770056
11718608_at
1294_at
15444
16954217
203281_s_at
2674763
2674764
2674766
2674768
2674771
2674772
2674773
2674775
2674777
2674779
2674780
2674781
2674782
2674784
2674785
2674787
2674790
2674791
2674792
2674794
2674796
2674797
2674798
2674799
2674801
2674802
2674804
2674805
2674806
2674807
58182
7318
8087485
A_23_P21207
CAB015444
CCDS2805
ENSG00000182179
ENSP00000333266
ENST00000333486
EntrezGene:7318
g4507766_3p_s_at
GE57635
GO:0000166
GO:0004839
GO:0004842
GO:0005515
GO:0005524
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006511
GO:0006974
GO:0008641
GO:0016567
GO:0016874
GO:0019782
GO:0019941
GO:0019985
GO:0032020
GO:0032480
HGNC:12471
HPA058182
Hs.16695
ILMN_1794612
L13852_at
MIM:191325
NM_003335
NP_003326
PF00899
PF09358
PF10585
PF16190
PF16191
PH_hs_0028782
PR01849
PWY-7511
SM00985
TC03001418.hg
UBA7
UBA7-201
uc003cxr.4
UPI000006E3F8
XM_005265430
XM_006713321
XM_011534070
XM_011534071
XM_011534072
XP_005265487
XP_006713384
XP_011532372
XP_011532373
XP_011532374
Participant Of
input
Activation of ISG15 by UBA7 E1 ligase
hasCandidate
E2 Ubiquitin-conjugating enzyme [cytosol]
Ubiquitin activating E1 enzymes [cytosol]
hasMember
E2 enzymes UbcH8/UBE1L [cytosol]
hasComponent
ISG15:UBA7 [cytosol]
output
Transfer of ISG15 from E1 to E2 (UBCH8)
Other forms of this molecule
UBA7 [nucleoplasm]
Inferred To
UBA7 [cytosol] (Arabidopsis thaliana)
UBA7 [cytosol] (Bos taurus)
UBA7 [cytosol] (Caenorhabditis elegans)
UBA7 [cytosol] (Canis familiaris)
UBA7 [cytosol] (Danio rerio)
UBA7 [cytosol] (Dictyostelium discoideum)
UBA7 [cytosol] (Drosophila melanogaster)
UBA7 [cytosol] (Gallus gallus)
UBA7 [cytosol] (Mus musculus)
UBA7 [cytosol] (Oryza sativa)
UBA7 [cytosol] (Plasmodium falciparum)
UBA7 [cytosol] (Rattus norvegicus)
UBA7 [cytosol] (Saccharomyces cerevisiae)
UBA7 [cytosol] (Schizosaccharomyces pombe)
UBA7 [cytosol] (Sus scrofa)
UBA7 [cytosol] (Taeniopygia guttata)
Homologues of UBA7 [cytosol] (Arabidopsis thaliana)
Homologues of UBA7 [cytosol] (Caenorhabditis elegans)
Homologues of UBA7 [cytosol] (Canis familiaris)
Homologues of UBA7 [cytosol] (Drosophila melanogaster)
Homologues of UBA7 [cytosol] (Mus musculus)
Homologues of UBA7 [cytosol] (Oryza sativa)
Homologues of UBA7 [cytosol] (Rattus norvegicus)
Homologues of UBA7 [cytosol] (Sus scrofa)
Homologues of UBA7 [cytosol] (Taeniopygia guttata)
Cross References
RefSeq
NP_003326.2
ZINC - Substances
UBA7_HUMAN
GeneCards
P41226
ZINC target
P41226
PRO
P41226
ZINC - Predictions - Purchasable
UBA7_HUMAN
HMDB Protein
HMDBP09311
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05161 ISG15
4
K168-PCNA-G157-ISG15 [nucleoplasm]
(R-HSA-5653744)
ISG15 [cytosol]
(R-HSA-936552)
K164-PCNA-G157-ISG15 [nucleoplasm]
(R-HSA-5653745)
ISG15 [nucleoplasm]
(R-HSA-5653665)
0.824
11
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