Reactome | UBA7 [cytosol]

UBA7 [cytosol]

Stable Identifier

R-HSA-936550

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UBE1L, Ubiquitin-like modifier-activating enzyme 7, UBA7_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P41226 UBA7

Gene Names

UBA7, UBE1L, UBE2

Chain

chain:1-1012

Reference Genes

BioGPS Gene:7318 UBA7

COSMIC (genes):UBA7 UBA7

CTD Gene:7318 UBA7

dbSNP Gene:7318 UBA7

ENSEMBL:ENSG00000182179.13 UBA7

HGNC:12471 UBA7

KEGG Gene (Homo sapiens):7318 UBA7

Monarch:7318 UBA7

NCBI Gene:7318 UBA7

OMIM:191325 UBA7

UCSC:P41226 UBA7

Reference Transcript

RefSeq:NM_003335.2 UBA7

Other Identifiers

0001770056

11718608_at

1294_PM_at

1294_at

16954217

203281_PM_s_at

203281_s_at

2674763

2674764

2674766

2674768

2674771

2674772

2674773

2674775

2674777

2674779

2674780

2674781

2674782

2674784

2674785

2674787

2674790

2674791

2674792

2674794

2674796

2674797

2674798

2674799

2674801

2674802

2674804

2674805

2674806

2674807

7318

8087485

A_23_P21207

GE57635

GO:0000166

GO:0004842

GO:0005515

GO:0005524

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006974

GO:0008641

GO:0016567

GO:0016740

GO:0016874

GO:0019782

GO:0019941

GO:0030163

GO:0032020

GO:0032446

GO:0036211

GO:0043226

GO:0140096

HMNXSV003027715

ILMN_1794612

L13852_at

PH_hs_0028782

TC03001418.hg

g4507766_3p_s_at

Participates

as a member of

E2 enzymes UbcH8/UBE1L [cytosol] (Homo sapiens)

as an input of

Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)

as an output of

Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)

as a component of

ISG15:UBA7 [cytosol] (Homo sapiens)

as a candidate of

Other forms of this molecule

UBA7 [nucleoplasm]

Inferred To

uba-1 [cytosol] (Caenorhabditis elegans)

uba1 [cytosol] (Xenopus tropicalis)

Uba7 [cytosol] (Mus musculus)

Uba7 [cytosol] (Rattus norvegicus)

Uba1 [cytosol] (Drosophila melanogaster)

UBA7 [cytosol] (Bos taurus)

UBA7 [cytosol] (Canis familiaris)

UBA7 [cytosol] (Danio rerio)

UBA7 [cytosol] (Dictyostelium discoideum)

UBA7 [cytosol] (Gallus gallus)

UBA7 [cytosol] (Plasmodium falciparum)

UBA7 [cytosol] (Sus scrofa)

phactr2 [cytosol] (Xenopus tropicalis)

Homologues of UBA7 [cytosol] (Danio rerio)

Homologues of UBA7 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_003326.2

OpenTargets

ENSG00000182179

GeneCards

P41226

ZINC - Substances

UBA7_HUMAN

HPA

ENSG00000182179-UBA7

ZINC target

P41226

Ensembl

ENSP00000333266, ENST00000333486, ENSG00000182179

PRO

P41226

Pharos - Targets

P41226

ZINC - Predictions - Purchasable

UBA7_HUMAN

HMDB Protein

HMDBP09311

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05161 ISG15	4	ISG15 [nucleoplasm] (R-HSA-5653665) ISG15 [cytosol] (R-HSA-936552) K168-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653744) K164-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653745)	0.836	10
UniProt:Q13148 TADBP			0.556	3