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CHMP6 [cytosol]
Stable Identifier
R-HSA-917736
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Charged multivesicular body protein 6, CHMP6_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Autophagosome maturation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
CHMP7 binds CC2D1B (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Late Events (Homo sapiens)
HCMV Final Envelopment (Homo sapiens)
ESCRT Regulator Complex [cytosol] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
HCMV Formation of Final Envelopment Complex (Homo sapiens)
ESCRT Regulator Complex [cytosol] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
Recruitment Of HIV Virion Budding Machinery (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
GSDMD forms ring‐shaped oligomers (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Endosomal Sorting Complex Required For Transport (ESCRT) (Homo sapiens)
ESCRT Disassembly (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
ESCRT-III/Cargo Complex [endosome membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
MVB Vesicle Formation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
ESCRT-III/Cargo Complex [endosome membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96FZ7 CHMP6
Gene Names
CHMP6, VPS20
Chain
initiator methionine:, chain:2-201
Reference Genes
BioGPS Gene:79643 CHMP6
COSMIC (genes):CHMP6 CHMP6
CTD Gene:79643 CHMP6
dbSNP Gene:79643 CHMP6
ENSEMBL:ENSG00000176108 CHMP6
ENSEMBL_homo_sapiens_GENE:ENSG00000176108.9 CHMP6
HGNC:25675 CHMP6
KEGG Gene (Homo sapiens):79643 CHMP6
Monarch:79643 CHMP6
NCBI Gene:79643 CHMP6
OMIM:610901 CHMP6
UCSC:Q96FZ7 CHMP6
Reference Transcript
RefSeq:NM_024591.4 CHMP6
Other Identifiers
11718589_at
11718590_at
16838737
218743_PM_at
218743_at
3737649
3737650
3737655
3737656
3737657
3737658
3737659
3737660
3737665
3737666
3737667
3737668
3737669
3737670
3737671
3737672
56326_at
79643
8010550
A_23_P10156
GO:0000278
GO:0000421
GO:0000776
GO:0000815
GO:0000910
GO:0001778
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005643
GO:0005694
GO:0005764
GO:0005765
GO:0005768
GO:0005771
GO:0005773
GO:0005828
GO:0005829
GO:0005856
GO:0005886
GO:0006900
GO:0006914
GO:0006997
GO:0007010
GO:0007034
GO:0007040
GO:0007059
GO:0007080
GO:0007175
GO:0010008
GO:0012505
GO:0015031
GO:0016020
GO:0016192
GO:0016236
GO:0023052
GO:0030163
GO:0030496
GO:0031410
GO:0031468
GO:0031902
GO:0032511
GO:0032585
GO:0036211
GO:0036258
GO:0039702
GO:0042060
GO:0042176
GO:0043162
GO:0043226
GO:0044877
GO:0046761
GO:0051469
GO:0061024
GO:0061763
GO:0061952
GO:0065003
GO:0070062
GO:0071985
GO:0090148
GO:0097352
GO:0140014
GO:1901673
GO:1902774
GO:1904902
GO:1904930
HMNXSV003029105
HMNXSV003043544
ILMN_1706397
ILMN_1731609
PH_hs_0002006
TC17000922.hg
g13375782_3p_at
Participates
as an output of
ESCRT Disassembly (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
as an input of
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
as a component of
ESCRT-III [cytosol] (Homo sapiens)
Other forms of this molecule
CHMP6 [endosome membrane]
Inferred To
CHMP6 [cytosol]
(Bos taurus)
CHMP6 [cytosol]
(Gallus gallus)
CHMP6 [cytosol]
(Sus scrofa)
Chmp6 [cytosol]
(Mus musculus)
Chmp6 [cytosol]
(Rattus norvegicus)
chmp6 [cytosol]
(Danio rerio)
chmp6 [cytosol]
(Dictyostelium discoideum)
chmp6 [cytosol]
(Xenopus tropicalis)
vps20 [cytosol]
(Schizosaccharomyces pombe)
Vps20 [cytosol]
(Drosophila melanogaster)
Ghost homologue of CHMP6 [cytosol]
(Canis familiaris)
VPS20 [cytosol]
(Saccharomyces cerevisiae)
vps-20 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_078867.2
OpenTargets
ENSG00000176108
GeneCards
Q96FZ7
HPA
ENSG00000176108-CHMP6
Ensembl
ENSP00000317468
,
ENST00000325167
,
ENSG00000176108
PRO
Q96FZ7
Pharos - Targets
Q96FZ7
PDB
2K3W
,
3HTU
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BRG1 VPS25
1
VPS25 [cytosol]
(R-HSA-917697)
0.749
7
UniProt:O14656-2 TOR1A
0.556
3
UniProt:P50570-2 DNM2
0.556
3
UniProt:Q16637 SMN1
2
SMN1 [nucleoplasm]
(R-HSA-191892)
SMN1 [cytosol]
(R-HSA-191839)
0.556
3
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