CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex

Stable Identifier
R-HSA-9668398
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, nuclear envelope
ReviewStatus
5/5
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CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex
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CHMP7 promotes the assembly of other ESCRT-III subunits at nuclear envelope fenestrations. It first binds CHMP4B, which in turn causes recruitment and assembly of other ESCRTIII subunits including CHMP2A, CHMP4A, CHMP3 and IST1 (Olmos et al. 2015, Vietri et al. 2015, Gu et al. 2017).
Literature References
PubMed ID Title Journal Year
26040713 ESCRT-III controls nuclear envelope reformation

Olmos, Y, Hodgson, L, Mantell, J, Verkade, P, Carlton, JG

Nature 2015
26040712 Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

Vietri, M, Schink, KO, Campsteijn, C, Wegner, CS, Schultz, SW, Christ, L, Thoresen, SB, Brech, A, Raiborg, C, Stenmark, H

Nature 2015
28242692 LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

Gu, M, LaJoie, D, Chen, OS, von Appen, A, Ladinsky, MS, Redd, MJ, Nikolova, L, Bjorkman, PJ, Sundquist, WI, Ullman, KS, Frost, A

Proc. Natl. Acad. Sci. U.S.A. 2017
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Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2019-11-25)
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