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IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane]
Stable Identifier
R-HSA-913412
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Participants
components
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane]
(Homo sapiens)
p-Y349,Y350,Y427-SHC1 [cytosol]
(Homo sapiens)
Participates
as a member of
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
Inferred To
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane]
(Bos taurus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane]
(Canis familiaris)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane]
(Gallus gallus)
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