Reactome | Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate

Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate

Stable Identifier

R-HSA-904864

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

glyoxylate + alanine => glycine + pyruvate [mitochondrial matrix]

ReviewStatus

5/5

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Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate

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Mitochondrial AGXT2 (alanine-glyoxylate transaminase 2) catalyzes the irreversible reaction of glyoxylate and alanine to form glycine and pyruvate (Rodionov et al. 2010). The active form of the enzyme is inferred to be a homotetramer from the properties of the homologous rat protein, which has been purified and characterized in vitro (Tamaki et al.990). Most conversion of glyoxylate to glycine in vivo appears to occur in the peroxisome, catalyzed by AGXT, and the physiological role of the AGXT2 reaction is unclear.

Literature References

PubMed ID	Title	Journal	Year
2158891	Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver Mizota, C, Kaneko, M, Kikugawa, M, Fujimoto, S, Tamaki, N	Eur J Biochem	1990
20018850	Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production Lentz, SR, Rodionov, RN, Stevens, JW, Murry, DJ, Vaulman, SF	J Biol Chem	2010