Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
HMGCL(1-325) [cytosol]
Stable Identifier
R-HSA-9033112
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Hydroxymethylglutaryl-CoA lyase, mitochondrial, HMGCL_HUMAN
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
HMGCL(1-325) [cytosol] (Homo sapiens)
PEX5S,L binds cargo proteins containing PTS1 (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
HMGCL(1-325) [cytosol] (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
HMGCL(1-325) [cytosol] (Homo sapiens)
PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
HMGCL(1-325) [cytosol] (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
HMGCL(1-325) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35914 HMGCL
Gene Names
HMGCL
Chain
transit peptide:1-27, chain:28-325
Reference Genes
BioGPS Gene:3155 HMGCL
COSMIC (genes):HMGCL HMGCL
CTD Gene:3155 HMGCL
dbSNP Gene:3155 HMGCL
ENSEMBL:ENSG00000117305 HMGCL
HGNC:5005 HMGCL
KEGG Gene (Homo sapiens):3155 HMGCL
Monarch:3155 HMGCL
NCBI Gene:3155 HMGCL
OMIM:613898 HMGCL
UCSC:P35914 HMGCL
Reference Transcript
RefSeq:NM_000191.2 HMGCL
RefSeq:NM_001166059.1 HMGCL
Other Identifiers
0003780341
11756250_s_at
16683423
202772_at
2401610
2401611
2401612
2401615
2401621
2401626
2401630
2401634
2401635
2401636
2401637
2401638
3155
38425_at
7913682
A_23_P145
GE57571
GE60540
GO:0000062
GO:0000287
GO:0001889
GO:0003674
GO:0003824
GO:0004419
GO:0005198
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005759
GO:0005777
GO:0005782
GO:0005829
GO:0006091
GO:0006520
GO:0006552
GO:0006629
GO:0006637
GO:0006790
GO:0006950
GO:0007005
GO:0007584
GO:0008104
GO:0008150
GO:0009056
GO:0009058
GO:0016829
GO:0016833
GO:0030145
GO:0031406
GO:0032991
GO:0034641
GO:0042594
GO:0043167
GO:0043226
GO:0044281
GO:0046872
GO:0046951
GO:0048856
GO:0070542
HMNXSV003022254
ILMN_1688095
ILMN_2122420
L07033_at
PH_hs_0026011
TC01005330.hg
g4504426_3p_at
Participates
as a member of
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
Other forms of this molecule
HMGCL(1-325) [peroxisomal matrix]
HMGCL [mitochondrial matrix]
Inferred To
hmgcl [cytosol]
(Danio rerio)
Hmgcl [cytosol]
(Drosophila melanogaster)
Hmgcl [cytosol]
(Mus musculus)
Hmgcl [cytosol]
(Rattus norvegicus)
HMGCL [cytosol]
(Sus scrofa)
HMGCL(1-325) [cytosol]
(Caenorhabditis elegans)
hmgL [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_000182.2
,
NP_001159531.1
OpenTargets
ENSG00000117305
GeneCards
P35914
HPA
ENSG00000117305-HMGCL
Ensembl
ENST00000374490
,
ENSP00000389281
,
ENST00000436439
,
ENSP00000363614
,
ENSG00000117305
PRO
P35914
Pharos - Targets
P35914
GlyGen
P35914
Orphanet
16207
HMDB Protein
HMDBP00009
PDB
3MP3
,
3MP4
,
2CW6
,
3MP5
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text