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HMGCL [mitochondrial matrix]
Stable Identifier
R-HSA-74172
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
hydroxymethylglutaryl-CoA lyase, Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase), HMG-CoA lyase, HL, 3-hydroxy-3-methylglutarate-CoA lyase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Ketone body metabolism (Homo sapiens)
Synthesis of Ketone Bodies (Homo sapiens)
HMG CoA => acetoacetic acid + acetyl CoA (Homo sapiens)
HMGCL dimer [mitochondrial matrix] (Homo sapiens)
HMGCL [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35914 HMGCL
Gene Names
HMGCL
Chain
transit peptide:1-27, chain:28-325
Reference Genes
BioGPS Gene:3155 HMGCL
COSMIC (genes):HMGCL HMGCL
CTD Gene:3155 HMGCL
dbSNP Gene:3155 HMGCL
ENSEMBL:ENSG00000117305 HMGCL
ENSEMBL_homo_sapiens_GENE:ENSG00000117305 HMGCL
HGNC:5005 HMGCL
KEGG Gene (Homo sapiens):3155 HMGCL
Monarch:3155 HMGCL
NCBI Gene:3155 HMGCL
OMIM:613898 HMGCL
UCSC:P35914 HMGCL
Reference Transcript
RefSeq:NM_001166059.1 HMGCL
RefSeq:NM_000191.2 HMGCL
Other Identifiers
0003780341
00072+4.1.3.4
00280+4.1.3.4
00281+4.1.3.4
00650+4.1.3.4
11756250_s_at
16683423
202772_at
2401610
2401611
2401612
2401615
2401621
2401626
2401630
2401634
2401635
2401636
2401637
2401638
2CW6
3155
38425_at
3MP3
3MP4
3MP5
4727
7913682
A_23_P145
AAA92733
AAB19099
AAH10570
AAP88794
ACK58684
ADD21697
AH003700
AK300733
AK313869
AL031295
AL590728
BAG36597
BAG62406
BC010570
BT009792
CAG33165
CCDS243
CCDS53279
CH471134
CR456884
D6REN8
EAW95094
ENSG00000117305
ENSP00000363614
ENSP00000389281
ENST00000374490
ENST00000436439
EntrezGene:3155
FJ472654
g4504426_3p_at
GE57571
GE60540
GO:0000062
GO:0000287
GO:0001889
GO:0003674
GO:0003824
GO:0004419
GO:0005102
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005739
GO:0005759
GO:0005777
GO:0005782
GO:0005829
GO:0006091
GO:0006520
GO:0006552
GO:0006605
GO:0006625
GO:0006629
GO:0006637
GO:0006790
GO:0006810
GO:0006950
GO:0007005
GO:0007584
GO:0008150
GO:0009056
GO:0009058
GO:0016829
GO:0022607
GO:0030145
GO:0031406
GO:0034641
GO:0042594
GO:0042803
GO:0043167
GO:0043226
GO:0044281
GO:0046872
GO:0046951
GO:0048856
GO:0051186
GO:0051262
GO:0065003
GO:0070542
GU433941
HGNC:5005
HMGCL
HMGCL-203
HMGCL-204
HPA004727
ILMN_1688095
ILMN_2122420
IPR000138
IPR000891
IPR013785
L07033
L07033_at
MIM:246450
MIM:613898
NM_000191
NM_001166059
NP_000182
NP_001159531
PF00682
PH_hs_0026011
TC01002351.hg
TC01005330.hg
uc001bib.4
uc010oec.3
UPI000012CA36
UPI000047EEB4
Participant Of
hasComponent
HMGCL dimer [mitochondrial matrix]
Other forms of this molecule
HMGCL(1-325) [peroxisomal matrix]
HMGCL(1-325) [cytosol]
Inferred To
HMGCL [mitochondrial matrix] (Arabidopsis thaliana)
HMGCL [mitochondrial matrix] (Bos taurus)
HMGCL [mitochondrial matrix] (Caenorhabditis elegans)
HMGCL [mitochondrial matrix] (Canis familiaris)
HMGCL [mitochondrial matrix] (Danio rerio)
HMGCL [mitochondrial matrix] (Dictyostelium discoideum)
HMGCL [mitochondrial matrix] (Drosophila melanogaster)
HMGCL [mitochondrial matrix] (Gallus gallus)
HMGCL [mitochondrial matrix] (Mus musculus)
HMGCL [mitochondrial matrix] (Oryza sativa)
HMGCL [mitochondrial matrix] (Rattus norvegicus)
HMGCL [mitochondrial matrix] (Sus scrofa)
HMGCL [mitochondrial matrix] (Taeniopygia guttata)
HMGCL [mitochondrial matrix] (Xenopus tropicalis)
Homologues of HMGCL [mitochondrial matrix] (Canis familiaris)
Homologues of HMGCL [mitochondrial matrix] (Drosophila melanogaster)
Homologues of HMGCL [mitochondrial matrix] (Gallus gallus)
Homologues of HMGCL [mitochondrial matrix] (Oryza sativa)
Homologues of HMGCL [mitochondrial matrix] (Sus scrofa)
Cross References
RefSeq
NP_001159531.1
,
NP_000182.2
OpenTargets
ENSG00000117305
GeneCards
P35914
DOCK Blaster
3MP3
,
2CW6
,
3MP4
,
3MP5
PRO
P35914
BRENDA (Homo sapiens)
4.1.3.4
Orphanet
16207
HMDB Protein
HMDBP00009
PDB
3MP5
,
3MP4
,
3MP3
,
2CW6
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