Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Plcg1,2

Stable Identifier
R-MMU-9027436
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Plcg1,2
Plcg1 (Phospholipase C gamma1) or Plcg2 binds phosphotyrosine-432 and phosphotyrosine-479 of Epor (Boudot et al. 1999, Boudot et al. 2002, Tong et al. 2004, Halupa et al. 2005, Schnoder et al. 2015). After binding, Plcg1,2 is phosphorylated (Boudot et al. 1999).
Literature References
PubMed ID Title Journal Year
15953601 Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma

Halupa, A, Chohan, M, Stickle, NH, Beattie, BK, Miller, BA, Barber, DL

Exp. Cell Res. 2005
25394487 Epo-induced erythroid maturation is dependent on Plcγ1 signaling

Schnöder, TM, Arreba-Tutusaus, P, Griehl, I, Bullinger, L, Buschbeck, M, Lane, SW, Döhner, K, Plass, C, Lipka, DB, Heidel, FH, Fischer, T

Cell Death Differ. 2015
10567359 Erythropoietin induces glycosylphosphatidylinositol hydrolysis. Possible involvement of phospholipase c-gamma(2)

Boudot, C, Petitfrère, E, Kadri, Z, Chrétien, S, Mayeux, P, Haye, B, Billat, C

J. Biol. Chem. 1999
15329338 Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R

Tong, Q, Chu, X, Cheung, JY, Conrad, K, Stahl, R, Barber, DL, Mignery, G, Miller, BA

Am. J. Physiol., Cell Physiol. 2004
12135708 Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells

Boudot, C, Kadri, Z, Petitfrère, E, Lambert, E, Chrétien, S, Mayeux, P, Haye, B, Billat, C

Cell. Signal. 2002
Participants
Input
Output
Orthologous Events
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma (Homo sapiens)
Authored
May, B  (2017-10-30)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-11-01)
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