p-Y817 of p-5Y-NTRK2 recruits PLCG1

Stable Identifier
R-HSA-9026531
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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p-Y817 of p-5Y-NTRK2 recruits PLCG1
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Autophosphorylated tyrosine Y817 of NTRK2 (corresponds to Y785 of the mature rat Ntrk2) is a docking site for PLCG1 (PLCgamma1), an activator of signaling via secondary messengers DAG and IP3 (Minichiello et al. 1998, McCarthy and Feinstein 1999, Minichiello et al. 2002). PLCG1 is recruited to Y817 of NTRK2 in response to BDNF stimulation (Minichiello et al. 1998, McCarthy and Feinstein 1999) and is also recruited to NTF4-activated NTRK2 (Minichiello et al. 1998). Recruitment on PLCG1 to NTRK2 in response to stimulation by NTF3 has not been examined.

Participants
Input
Output
Participant Of
hasEvent
Inferred From
BDNF- or NTF4-activated Ntrk2 recruits Plcg1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-10-20)