BDNF- or NTF4-activated Ntrk2 recruits Plcg1

Stable Identifier
R-NUL-9030433
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
BDNF- or NTF4-activated Ntrk2 recruits Plcg1
Mouse Plcg1 is recruited to autophosphorylated mouse Ntrk2 in response to stimulation with recombinant human BDNF or NTF4 (Minichiello et al. 1998, Minichiello et al. 2002).
Literature References
PubMed ID Title Journal Year
9728915 Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses

Minichiello, L, Casagranda, F, Tatche, RS, Stucky, CL, Postigo, A, Lewin, GR, Davies, AM, Klein, R

Neuron 1998
12367511 Mechanism of TrkB-mediated hippocampal long-term potentiation

Minichiello, L, Calella, AM, Medina, DL, Bonhoeffer, T, Klein, R, Korte, M

Neuron 2002
Participants
Input
Output
Orthologous Events
p-Y817 of p-5Y-NTRK2 recruits PLCG1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-11-28)
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